A complete list of publications by Prof Peter Olupot Olupot. Use the filters to refine by year, journal or keyword.

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1. 2026
   Incidence of clinically diagnosed infections in children with sickle cell anaemia treated with oral hydroxyurea in Angola, DR Congo, Kenya, and Uganda: a retrospective cohort study from the REACH trial

   Williams, T. N. Smart, L. R. Tomlinson, G. Santos, et al.

   Lancet Haematol. 2026

   View abstract DOI PubMed
2. 2026
   Intravenous Artesunate in Artemisinin-Resistant Severe Malaria in Uganda

   Maitland, K. Okao, M. Conrad, M. D. Etwop, et al.

   N Engl J Med. 2026; 394:2380-2382

   View abstract DOI PubMed
3. 2026
   Growth and puberty in African children with sickle cell anemia treated with hydroxyurea

   Backeljauw, P. Tomlinson, G. Smart, L. R. Tshilolo, et al.

   Blood Adv. 2026; 10:4483-4494

   View abstract DOI PubMed
4. 2026
   Nasopharyngeal Microbiome Composition and its Clinical Correlates in Children Hospitalized with Severe Pneumonia in East Africa

   Makori, T. O. Gicheru, E. T. Mburu, M. W. Sada, et al.

   J Infect Dis. 2026

   View abstract DOI PubMed
5. 2026
   Oral rehydration for severe malnutrition in children with moderate and severe dehydration (GASTROSAM): a phase 2, open-label, superiority randomised controlled trial

   Maitland, K. Sainna, H. Connon, R. Ouattara, et al.

   Lancet Child Adolesc Health. 2026; 10:319-329

   View abstract DOI PubMed
6. 2026
   Hydroxyurea pharmacokinetics in children with sickle cell anemia across different global populations

   Power-Hays, A. McElhinney, K. E. Williams, T. N. Mochamah, et al.

   Blood Adv. 2026; 10:418-427

   View abstract DOI PubMed
7. 2026
   A cost-consequence analysis of the children's administration oxygenation strategies trial (COAST) in severe pneumonia

   Carroll, O. U. Grieve, R. Kiguli, S. Olupot-Olupot, et al.

   PLOS Glob Public Health. 2026; 6:e0005654

   View abstract DOI PubMed
8. 2026
   Gut microbial diversity impacts carbohydrate fermentation by children with severe acute malnutrition

   Bisht, A. Ahn-Jarvis, J. Corbin, K. Harris, et al.

   iScience. 2026; 29:114640

   View abstract DOI PubMed
9. 2025
   Single low dose primaquine to block the transmission of Plasmodium falciparum-proposed stand-alone and ACT-adapted regimens

   Taylor, W. R. J. Olupot-Olupot, P. Onyamboko, M. A. Chimjinda, et al.

   BMC Med. 2025; 23:397

   View abstract DOI PubMed
10. 2025
    Epidemiological dynamics of influenza B virus across multiple seasons in Kenya and Uganda inferred from sequence data, 2010-2021

    Nyarango, B. K. Owuor, D. C. Isoe, E. Mutunga, et al.

    BMC Infect Dis. 2025; 25:1080

    View abstract DOI PubMed
11. 2025
    Effect of nutritional supplementation with lipid-based therapeutic food on body composition of non-severely malnourished African children aged 6-59 months hospitalized with severe pneumonia

    Nalwanga, D. Musiime, V. Kiguli, S. Olupot-Olupot, et al.

    J Trop Pediatr. 2025; 71

    View abstract DOI PubMed
12. 2025
    Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis

    Maitland, K. Ouattara, S. M. Sainna, H. Chara, et al.

    N Engl J Med. 2025; 393:1257-1268

    View abstract DOI PubMed
13. 2025
    Early weaning from oxygen therapy in African children with severe pneumonia

    Maitland, K. Giallongo, E. Hamaluba, M. Alaroker, et al.

    BMC Med. 2025; 23:366

    View abstract DOI PubMed
14. 2025
    Catastrophic expenditure associated with childhood hospitalisation for acute illness in Kenya and Uganda: a cross-sectional study

    Jemutai, J. Njuguna, R. G. Laurence, Y. V. Murunga, et al.

    BMJ Public Health. 2025; 3:e001173

    View abstract DOI PubMed
15. 2025
    Comparing HemoCue(R) and Quantitative Buffy Coat(R) and Coulter Counter-measured haemoglobin concentrations in African children with acute uncomplicated malaria: a Bland-Altman analysis

    Ayuen, D. S. Olupot-Olupot, P. Muhindo, R. Onyamboko, et al.

    Malar J. 2025; 24:77

    View abstract DOI PubMed
16. 2025
    Plasma folate dynamics in Plasmodium falciparum-infected African children treated with artemisinin combination therapy and single low-dose primaquine or placebo

    Ajayi, S. Onyamboko, M. A. Olupot-Olupot, P. Ayuen, et al.

    Malar J. 2025; 24:342

    View abstract DOI PubMed
17. 2024
    Legume-supplemented feed for children hospitalised with severe malnutrition: a phase II trial

    Walsh, K. Kiosa, A. Olupot-Olupot, P. Alaroker, et al.

    Br J Nutr. 2024; 132:372-381

    View abstract DOI PubMed
18. 2024
    Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial

    Power-Hays, A. Tomlinson, G. A. Tshilolo, L. Santos, et al.

    Am J Hematol. 2024; 99:625-632

    View abstract DOI PubMed
19. 2021
    Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol

    Olupot-Olupot, P. Aloroker, F. Mpoya, A. Mnjalla, et al.

    Wellcome Open Res. 2021; 6:160

    View abstract DOI PubMed
20. 2024
    Is fat mass a better predictor of 6-month survival than muscle mass among African children aged 6-59 months with severe pneumonia?

    Nalwanga, D. Musiime, V. Kiguli, S. Olupot-Olupot, et al.

    BMC Nutr. 2024; 10:130

    View abstract DOI PubMed
21. 2024
    Nutritional supplementation in children with severe pneumonia in Uganda and Kenya (COAST-Nutrition): a phase 2 randomised controlled trial

    Kiguli, S. Olupot-Olupot, P. Hamaluba, M. Giallongo, et al.

    EClinicalMedicine. 2024; 72:102640

    View abstract DOI PubMed
22. 2024
    Azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a phase II randomised controlled trial

    Connon, R. Olupot-Olupot, P. Pistorius, A. M. A. Okiror, et al.

    BMC Med. 2024; 22:516

    View abstract DOI PubMed
23. 2024
    Hydroxyurea dose optimisation for children with sickle cell anaemia in sub-Saharan Africa (REACH): extended follow-up of a multicentre, open-label, phase 1/2 trial

    Aygun, B. Lane, A. Smart, L. R. Santos, et al.

    Lancet Haematol. 2024; 11:e425-e435

    View abstract DOI PubMed
24. 2023
    Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial

    Taylor, W. R. Olupot-Olupot, P. Onyamboko, M. A. Peerawaranun, et al.

    Lancet Infect Dis. 2023; 23:471-483

    View abstract DOI PubMed
25. 2023
    Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo

    Onyamboko, M. A. Olupot-Olupot, P. Were, W. Namayanja, et al.

    BMC Med. 2023; 21:397

    View abstract DOI PubMed
26. 2023
    Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa

    Olupot-Olupot, P. Tomlinson, G. Williams, T. N. Tshilolo, et al.

    Blood. 2023; 141:1402-1410

    View abstract DOI PubMed
27. 2021
    Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial

    Olupot-Olupot, P. Okiror, W. Mnjalla, H. Muhindo, et al.

    Wellcome Open Res. 2021; 6:161

    View abstract DOI PubMed
28. 2023
    Cardiovascular abnormalities in chest radiographs of children with pneumonia, Uganda

    Nabawanuka, E. Ameda, F. Erem, G. Bugeza, et al.

    Bull World Health Organ. 2023; 101:202-210

    View abstract DOI PubMed
29. 2023
    Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria

    Mukaka, M. Onyamboko, M. A. Olupot-Olupot, P. Peerawaranun, et al.

    EBioMedicine. 2023; 96:104805

    View abstract DOI PubMed
30. 2022
    Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT)

    Uyoga, S. Olupot-Olupot, P. Connon, R. Kiguli, et al.

    Lancet Child Adolesc Health. 2022; 6:606-613

    View abstract DOI PubMed
31. 2022
    A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa

    Olupot-Olupot, P. Connon, R. Kiguli, S. Opoka, et al.

    Am J Hematol. 2022; 97:527-536

    View abstract DOI PubMed
32. 2022
    A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era

    Obonyo, N. G. Olupot-Olupot, P. Mpoya, A. Nteziyaremye, et al.

    Pediatr Crit Care Med. 2022; 23:502-513

    View abstract DOI PubMed
33. 2022
    High false discovery rate of the Architect anti-HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing

    Lucey, O. Acana, S. Olupot-Olupot, P. Muhindo, et al.

    Vox Sang. 2022; 117:1360-1367

    View abstract DOI PubMed
34. 2022
    Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial

    George, E. C. Uyoga, S. M'Baya, B. Kyeyune Byabazair, et al.

    Lancet Glob Health. 2022; 10:e360-e368

    View abstract DOI PubMed
35. 2021
    Point-of-care haemoglobin testing in African hospitals: a neglected essential diagnostic test

    Uyoga, S. George, E. C. Bates, I. Olupot-Olupot, et al.

    Br J Haematol. 2021; 193:894-901

    View abstract DOI PubMed
36. 2021
    Transfusion management of severe anaemia in African children: a consensus algorithm

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Opoka, et al.

    Br J Haematol. 2021; 193:1247-1259

    View abstract DOI PubMed
37. 2021
    Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Hamaluba, et al.

    Intensive Care Med. 2021; 47:566-576

    View abstract DOI PubMed
38. 2021
    Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data

    Connon, R. George, E. C. Olupot-Olupot, P. Kiguli, et al.

    BMC Public Health. 2021; 21:1480

    View abstract DOI PubMed
39. 2021
    Modifying gut integrity and microbiome in children with severe acute malnutrition using legume-based feeds (MIMBLE): A pilot trial

    Calder, N. Walsh, K. Olupot-Olupot, P. Ssenyondo, et al.

    Cell Rep Med. 2021; 2:100280

    View abstract DOI PubMed
40. 2020
    Characterising demographics, knowledge, practices and clinical care among patients attending sickle cell disease clinics in Eastern Uganda

    Olupot-Olupot, P. Wabwire, H. Ndila, C. Adong, et al.

    Wellcome Open Res. 2020; 5:87

    View abstract DOI PubMed
41. 2020
    The clinical spectrum of severe childhood malaria in Eastern Uganda

    Olupot-Olupot, P. Engoru, C. Nteziyaremye, J. Chebet, et al.

    Malar J. 2020; 19:322

    View abstract DOI PubMed
42. 2020
    Development and Validation of an Objective, Passive Dietary Assessment Method for Estimating Food and Nutrient Intake in Households in Low- and Middle-Income Countries: A Study Protocol

    Jobarteh, M. L. McCrory, M. A. Lo, B. Sun, et al.

    Curr Dev Nutr. 2020; 4:nzaa020

    View abstract DOI PubMed
43. 2019
    Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa

    Uyoga, S. Mpoya, A. Olupot-Olupot, P. Kiguli, et al.

    Vox Sang. 2019; 114:340-348

    View abstract DOI PubMed
44. 2019
    Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa

    Tshilolo, L. Tomlinson, G. Williams, T. N. Santos, et al.

    N Engl J Med. 2019; 380:121-131

    View abstract DOI PubMed
45. 2019
    Transfusion Timing and Volume in African Children with Severe Anemia. Reply

    Maitland, K. Olupot-Olupot, P. Walker, A. S.

    N Engl J Med. 2019; 381:1687-1688

    View abstract DOI PubMed
46. 2019
    Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial

    Maitland, K. Olupot-Olupot, P. Kiguli, S. Chagaluka, et al.

    Lancet Glob Health. 2019; 7:e1435-e1447

    View abstract DOI PubMed
47. 2019
    Transfusion Volume for Children with Severe Anemia in Africa

    Maitland, K. Olupot-Olupot, P. Kiguli, S. Chagaluka, et al.

    N Engl J Med. 2019; 381:420-431

    View abstract DOI PubMed
48. 2019
    Immediate Transfusion in African Children with Uncomplicated Severe Anemia

    Maitland, K. Kiguli, S. Olupot-Olupot, P. Engoru, et al.

    N Engl J Med. 2019; 381:407-419

    View abstract DOI PubMed
49. 2019
    Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

    Houston, K. A. Gibb, J. Olupot-Olupot, P. Obonyo, et al.

    BMC Med. 2019; 17:122

    View abstract DOI PubMed
50. 2019
    Healthcare-provider perceptions of barriers to oxygen therapy for paediatric patients in three government-funded eastern Ugandan hospitals; a qualitative study

    Dauncey, J. W. Olupot-Olupot, P. Maitland, K.

    BMC Health Serv Res. 2019; 19:335

    View abstract DOI PubMed
51. 2018
    Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial

    Walsh, K. Calder, N. Olupot-Olupot, P. Ssenyondo, et al.

    Wellcome Open Res. 2018; 3:95

    View abstract DOI PubMed
52. 2018
    Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda

    Olupot-Olupot, P. Prevatt, N. Engoru, C. Nteziyaremye, et al.

    Wellcome Open Res. 2018; 3:130

    View abstract DOI PubMed
53. 2018
    Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa

    McGann, P. T. Williams, T. N. Olupot-Olupot, P. Tomlinson, et al.

    Am J Hematol. 2018; 93:537-545

    View abstract DOI PubMed
54. 2018
    Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria

    Kotlyar, S. Olupot-Olupot, P. Nteziyaremye, J. Akech, et al.

    Pediatr Crit Care Med. 2018; 19:179-185

    View abstract DOI PubMed
55. 2018
    Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa

    Aramburo, A. Todd, J. George, E. C. Kiguli, et al.

    BMC Med. 2018; 16:37

    View abstract DOI PubMed
56. 2017
    High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda

    Olupot-Olupot, P. Engoru, C. Uyoga, S. Muhindo, et al.

    Clin Infect Dis. 2017; 64:939-946

    View abstract DOI PubMed
57. 2017
    Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)

    Obonyo, N. Brent, B. Olupot-Olupot, P. Boele van Hensbroek, et al.

    Crit Care. 2017; 21:103

    View abstract DOI PubMed
58. 2017
    The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study

    Nardo-Marino, A. Williams, T. N. Olupot-Olupot, P.

    BMC Hematol. 2017; 17:14

    View abstract DOI PubMed
59. 2017
    Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia

    Maitland, K. Kiguli, S. Opoka, R. O. Olupot-Olupot, et al.

    Wellcome Open Res. 2017; 2:100

    View abstract DOI PubMed
60. 2017
    Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration

    Houston, K. A. Gibb, J. G. Mpoya, A. Obonyo, et al.

    Wellcome Open Res. 2017; 2:62

    View abstract DOI PubMed
61. 2016
    Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessment

    Nightingale, H. Walsh, K. J. Olupot-Olupot, P. Engoru, et al.

    BMC Nutr. 2016; 2

    View abstract DOI PubMed
62. 2016
    Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub-Saharan Africa: Rationale and Design of the REACH Trial

    McGann, P. T. Tshilolo, L. Santos, B. Tomlinson, et al.

    Pediatr Blood Cancer. 2016; 63:98-104

    View abstract DOI PubMed
63. 2016
    Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury

    Church, J. A. Nyamako, L. Olupot-Olupot, P. Maitland, et al.

    Malar J. 2016; 15:54

    View abstract DOI PubMed
64. 2015
    Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial

    Mpoya, A. Kiguli, S. Olupot-Olupot, P. Opoka, et al.

    Trials. 2015; 16:593

    View abstract DOI PubMed
65. 2015
    Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness

    Kiguli, S. Maitland, K. George, E. C. Olupot-Olupot, et al.

    BMC Med. 2015; 13:21

    View abstract DOI PubMed
66. 2015
    Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score

    George, E. C. Walker, A. S. Kiguli, S. Olupot-Olupot, et al.

    BMC Med. 2015; 13:174

    View abstract DOI PubMed
67. 2014
    Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

    Olupot-Olupot, P. Engoru, C. Thompson, J. Nteziyaremye, et al.

    BMC Med. 2014; 12:67

    View abstract DOI PubMed
68. 2014
    Spleen volume and clinical disease manifestations of severe Plasmodium falciparum malaria in African children

    Kotlyar, S. Nteziyaremye, J. Olupot-Olupot, P. Akech, et al.

    Trans R Soc Trop Med Hyg. 2014; 108:283-9

    View abstract DOI PubMed
69. 2014
    Authors' reply to Southall

    Kiguli, S. Akech, S. O. Mtove, G. Opoka, et al.

    BMJ. 2014; 348:g1619

    View abstract DOI PubMed
70. 2014
    WHO guidelines on fluid resuscitation in children: missing the FEAST data

    Kiguli, S. Akech, S. O. Mtove, G. Opoka, et al.

    BMJ. 2014; 348:f7003

    View abstract DOI PubMed
71. 2013
    Endotoxaemia is common in children with Plasmodium falciparum malaria

    Olupot-Olupot, P. Urban, B. C. Jemutai, J. Nteziyaremye, et al.

    BMC Infect Dis. 2013; 13:117

    View abstract DOI PubMed
72. 2013
    Management of severe malaria: results from recent trials

    Olupot-Olupot, P. Maitland, K.

    Adv Exp Med Biol. 2013; 764:241-50

    View abstract DOI PubMed
73. 2013
    'The words will pass with the blowing wind': staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two African hospitals

    Molyneux, S. Njue, M. Boga, M. Akello, et al.

    PLoS One. 2013; 8:e54894

    View abstract DOI PubMed
74. 2013
    Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial

    Maitland, K. George, E. C. Evans, J. A. Kiguli, et al.

    BMC Med. 2013; 11:68

    View abstract DOI PubMed
75. 2011
    Mortality after fluid bolus in African children with severe infection

    Maitland, K. Kiguli, S. Opoka, R. O. Engoru, et al.

    N Engl J Med. 2011; 364:2483-95

    View abstract DOI PubMed