A complete list of publications by Prof. Francis Ndungu. Use the filters to refine by year, journal or keyword.

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1. 2026
   Baseline Treg frequency, Treg-associated immune checkpoint responses, and plasma IL-10 responses during controlled human malaria infection in semi-immune Kenyan adults: a secondary analysis of the CHMI-SIKA Study

   Kimenyi, K. M. Morter, R. Nyabundi, D. Orindi, et al.

   Lancet Microbe. 2026; 101375

   View abstract DOI PubMed
2. 2026
   Baseline Treg frequency, Treg-associated immune checkpoint responses, and plasma IL-10 responses during controlled human malaria infection in semi-immune Kenyan adults: a secondary analysis of the CHMI-SIKA Study

   Kimenyi, K. M. Morter, R. Nyabundi, D. Orindi, et al.

   Lancet Microbe. 2026; 101375

   View abstract DOI PubMed
3. 2026
   A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study

   Safari, M. S. Makori, T. O. Gicheru, E. T. Mburu, et al.

   Elife. 2026; 14

   View abstract DOI PubMed
4. 2026
   Cumulative Plasmodium falciparum infections do not drive long-term telomere shortening in Kenyan children

   Miglar, A. Amadi, D. Grannas, D. Widman, et al.

   Front Cell Infect Microbiol. 2026; 16:1750881

   View abstract DOI PubMed
5. 2026
   African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

   Muriuki, J. M. Mentzer, A. J. Band, G. Chong, et al.

   Nat Commun. 2026; 17

   View abstract DOI PubMed
6. 2026
   Pre-COVID-19 ex vivo cross-reactive IFN-gamma cellular response to SARS-CoV-2 spike overlapping peptides is more prevalent among Kenyan compared to Swedish adults

   Wanjiku, P. Orindi, B. Mwacharo, J. Chemweno, et al.

   BMC Infect Dis. 2026; 26:174

   View abstract DOI PubMed
7. 2025
   Induction of an early IFN-gamma cellular response and high plasma levels of SDF-1alpha are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients

   Wanjiku, P. Orindi, B. Kimotho, J. Sayed, et al.

   PLoS One. 2025; 20:e0316967

   View abstract DOI PubMed
8. 2025
   OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

   Mogire, R. M. Muriuki, J. M. Bayimenye, R. F. Mentzer, et al.

   medRxiv. 2025

   View abstract DOI PubMed
9. 2025
   Development of an oral regimen of unithiol for the treatment of snakebite envenoming: a phase 1 open-label dose-escalation safety trial and pharmacokinetic analysis in healthy Kenyan adults

   Abouyannis, M. Nyambura, Y. K. Ngome, S. Riako, et al.

   EBioMedicine. 2025; 113:105600

   View abstract DOI PubMed
10. 2024
    Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings

    Mugo, R. M. Rausch, S. Musimbi, Z. D. Strube, et al.

    PLoS Negl Trop Dis. 2024; 18:e0012279

    View abstract DOI PubMed
11. 2023
    Correlations between three ELISA protocols measurements of RTS,S/AS01-induced anti-CSP IgG antibodies

    Mugo, R. M. Orindi, B. Shee, F. M. Bellamy, et al.

    PLoS One. 2023; 18:e0286117

    View abstract DOI PubMed
12. 2022
    Transcriptomic signatures induced by the Ebola virus vaccine rVSVDeltaG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

    Vianello, E. Gonzalez-Dias, P. van Veen, S. Engele, et al.

    Lancet Microbe. 2022; 3:e113-e123

    View abstract DOI PubMed
13. 2022
    Vitamin D Deficiency and Its Association with Iron Deficiency in African Children

    Mogire, R. M. Muriuki, J. M. Morovat, A. Mentzer, et al.

    Nutrients. 2022; 14

    View abstract DOI PubMed
14. 2022
    Plasmodium falciparum-Specific Memory B-Cell and Antibody Responses Are Associated With Immunity in Children Living in an Endemic Area of Kenya

    Jahnmatz, P. Nyabundi, D. Sundling, C. Widman, et al.

    Front Immunol. 2022; 13:799306

    View abstract DOI PubMed
15. 2022
    10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity

    Addy, J. W. G. Bediako, Y. Ndungu, F. M. Valetta, et al.

    Wellcome Open Res. 2022; 6:79

    View abstract DOI PubMed
16. 2022
    TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)

    Abouyannis, M. FitzGerald, R. Ngama, M. Mwangudzah, et al.

    Wellcome Open Res. 2022; 7:90

    View abstract DOI PubMed
17. 2021
    Chronic Immune Activation and CD4(+) T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy

    Wolday, D. Ndungu, F. M. Gomez-Perez, G. P. de Wit, et al.

    Front Immunol. 2021; 12:693269

    View abstract DOI PubMed
18. 2021
    Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

    Sutton, H. J. Aye, R. Idris, A. H. Vistein, et al.

    Cell Rep. 2021; 34:108684

    View abstract DOI PubMed
19. 2021
    Malaria is a cause of iron deficiency in African children

    Muriuki, J. M. Mentzer, A. J. Mitchell, R. Webb, et al.

    Nat Med. 2021; 27:653-658

    View abstract DOI PubMed
20. 2021
    Prevalence and predictors of vitamin D deficiency in young African children

    Mogire, R. M. Morovat, A. Muriuki, J. M. Mentzer, et al.

    BMC Med. 2021; 19:115

    View abstract DOI PubMed
21. 2021
    Iron Deficiency Is Associated With Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children

    Bundi, C. K. Nalwoga, A. Lubyayi, L. Muriuki, et al.

    Clin Infect Dis. 2021; 73:43-49

    View abstract DOI PubMed
22. 2020
    B-cell memory in malaria: Myths and realities

    Perez-Mazliah, D. Ndungu, F. M. Aye, R. Langhorne, et al.

    Immunol Rev. 2020; 293:57-69

    View abstract DOI PubMed
23. 2020
    Estimating the burden of iron deficiency among African children

    Muriuki, J. M. Mentzer, A. J. Webb, E. L. Morovat, et al.

    BMC Med. 2020; 18:31

    View abstract DOI PubMed
24. 2020
    Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype

    Aye, R. Sutton, H. J. Nduati, E. W. Kai, et al.

    Eur J Immunol. 2020; 50:1187-1194

    View abstract DOI PubMed
25. 2019
    A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01 (E) on blood stage immunity in young Kenyan children

    Ndungu, F. M. Mwacharo, J. Wambua, J. Njuguna, et al.

    Wellcome Open Res. 2019; 4:42

    View abstract DOI PubMed
26. 2019
    Iron Status and Associated Malaria Risk Among African Children

    Muriuki, J. M. Mentzer, A. J. Kimita, W. Ndungu, et al.

    Clin Infect Dis. 2019; 68:1807-1814

    View abstract DOI PubMed
27. 2019
    The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

    Muriuki, J. M. Mentzer, A. J. Band, G. Gilchrist, et al.

    Sci Adv. 2019; 5:eaaw0109

    View abstract DOI PubMed
28. 2019
    Longitudinal Analysis of Infant Stool Bacteria Communities Before and After Acute Febrile Malaria and Artemether-Lumefantrine Treatment

    Mandal, R. K. Crane, R. J. Berkley, J. A. Gumbi, et al.

    J Infect Dis. 2019; 220:687-698

    View abstract DOI PubMed
29. 2019
    Repeated clinical malaria episodes are associated with modification of the immune system in children

    Bediako, Y. Adams, R. Reid, A. J. Valletta, et al.

    BMC Med. 2019; 17:60

    View abstract DOI PubMed
30. 2018
    Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study

    Huttner, A. Agnandji, S. T. Combescure, C. Fernandes, et al.

    Lancet Infect Dis. 2018; 18:738-748

    View abstract DOI PubMed
31. 2017
    Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

    Pieper, K. Tan, J. Piccoli, L. Foglierini, et al.

    Nature. 2017; 548:597-601

    View abstract DOI PubMed
32. 2016
    The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum - an epidemiological "natural experiment"

    Bediako, Y. Ngoi, J. M. Nyangweso, G. Wambua, et al.

    BMC Med. 2016; 14:143

    View abstract DOI PubMed
33. 2015
    Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models

    Ndungu, F. M. Marsh, K. Fegan, G. Wambua, et al.

    BMC Med. 2015; 13:183

    View abstract DOI PubMed
34. 2014
    Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children

    Olotu, A. Clement, F. Jongert, E. Vekemans, et al.

    PLoS One. 2014; 9:e115126

    View abstract DOI PubMed
35. 2013
    Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion

    Illingworth, J. Butler, N. S. Roetynck, S. Mwacharo, et al.

    J Immunol. 2013; 190:1038-47

    View abstract DOI PubMed
36. 2012
    High efficiency human memory B cell assay and its application to studying Plasmodium falciparum-specific memory B cells in natural infections

    Weiss, G. E. Ndungu, F. M. McKittrick, N. Li, et al.

    J Immunol Methods. 2012; 375:68-74

    View abstract DOI PubMed
37. 2012
    Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children

    Ndungu, F. M. Olotu, A. Mwacharo, J. Nyonda, et al.

    Proc Natl Acad Sci U S A. 2012; 109:8247-52

    View abstract DOI PubMed
38. 2012
    A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E

    Ndungu, F. M. Mwacharo, J. Kimani, D. Kai, et al.

    PLoS One. 2012; 7:e52870

    View abstract DOI PubMed
39. 2012
    Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya

    Ibison, F. Olotu, A. Muema, D. M. Mwacharo, et al.

    PLoS One. 2012; 7:e52939

    View abstract DOI PubMed
40. 2011
    Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study

    Muema, D. K. Ndungu, F. M. Kinyanjui, S. M. Berkley, et al.

    Malar J. 2011; 10:55

    View abstract DOI PubMed
41. 2010
    Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice

    Nduati, E. W. Ng, D. H. Ndungu, F. M. Gardner, et al.

    PLoS One. 2010; 5:e15007

    View abstract DOI PubMed
42. 2009
    Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells

    Stephens, R. Ndungu, F. M. Langhorne, J.

    Parasite Immunol. 2009; 31:20-31

    View abstract DOI PubMed
43. 2008
    Immunity to malaria: more questions than answers

    Langhorne, J. Ndungu, F. M. Sponaas, A. M. Marsh, et al.

    Nat Immunol. 2008; 9:725-32

    View abstract DOI PubMed
44. 2006
    CD4 T cells from malaria-nonexposed individuals respond to the CD36-Binding Domain of Plasmodium falciparum erythrocyte membrane protein-1 via an MHC class II-TCR-independent pathway

    Ndungu, F. M. Sanni, L. Urban, B. Stephens, et al.

    J Immunol. 2006; 176:5504-12

    View abstract DOI PubMed
45. 2005
    Regulation of immune response by Plasmodium-infected red blood cells

    Ndungu, F. M. Urban, B. C. Marsh, K. Langhorne, et al.

    Parasite Immunol. 2005; 27:373-84

    View abstract DOI PubMed
46. 2005
    B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area

    Dorfman, J. R. Bejon, P. Ndungu, F. M. Langhorne, et al.

    J Infect Dis. 2005; 191:1623-30

    View abstract DOI PubMed
47. 2005
    Plasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severity

    Bull, P. C. Pain, A. Ndungu, F. M. Kinyanjui, et al.

    J Infect Dis. 2005; 192:1119-26

    View abstract DOI PubMed
48. 2002
    Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2

    Ndungu, F. M. Bull, P. C. Ross, A. Lowe, et al.

    Parasite Immunol. 2002; 24:77-82

    View abstract DOI PubMed