Prof. Kathryn Maitland

Principal Investigator

kathryn.maitland@gmail.com

Biography

Professor of Paediatric Tropical Infectious Diseases at the Faculty of Medicine and Director of the ICCARE Centre at the Global Centre of Health Innovation, Imperial College, London and an Honorary Fellow at MRC Clinical Trials Unit, University College, London. Over the last 20 years she has been based full-time at the East Africa, where she leads a research group that have highlighted the unique importance of emergency-care research as a highly targeted and cost-effective means of tackling childhood mortality in resource-limited sub-Saharan Africa hospitals. Her team conducted the largest trial in critically children ever undertaken in Africa (FEAST trial) examining fluid resuscitation strategies in children with severe febrile illness, showing that fluid boluses increased mortality. Her team has recently completed Phase III factorial trial of transfusion and other treatment strategies in 4000 African children with severe life-threatening anaemia (TRACT)

Current Work

Her major research portfolio includes severe malaria, bacterial sepsis and severe malnutrition. Her team recently completed the COAST (Children’s Oxygenation Administration Strategies Trial) investigating who needs oxygen and how best to administer it in 1842 children providing new evidence that respiratory support with H Flow Nasal Therapy might reduce mortality and that oxygen sparing strategies employed in the COAST trial was safe. Through a collaborative award in science from Wellcome she leads SMAART (A Severe Malaria Africa – A consortium for Research and Trials) consortium- a multi-disciplinary team whose membership includes world leaders in severe malaria and experts in clinical trials. The overarching aim of SMAART is to improve outcomes from severe malaria in African children by conducting an umbrella trial, investigating multiple interventions in parallel, to enable evidence-based updates of treatment guidelines for severe malaria.

Top 5 Publications

Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia.

Maitland K, Kiguli S, Olupot-Olupot P, Hamaluba M, Thomas K, Alaroker F, Opoka RO, Tagoola A, Bandika V, Mpoya A, Mnjella H, Nabawanuka E, Okiror W, Nakuya M, Aromut D, Engoru C, Oguda E, Williams TN, Fraser JF, Harrison DA, Rowan K; COAST trial group.

Intensive Care Med. 2021. 2021; : doi: 10.1007/s00134-021-06385-3.

Transfusion Volume for Children with Severe Anemia in Africa.

Maitland, K., Olupot-Olupot, P., Kiguli, S., Chagaluka, G., Alaroker, F., Opoka, R.O., Mpoya, A., Engoru, C., Nteziyaremye, J., Mallewa, M., Kennedy, N., Nakuya, M., Namayanja, C., Kayaga, J., Uyoga, S., Kyeyune Byabazaire, D., M'baya, B., Wabwire, B., Frost, G., Bates, I., Evans, J.A., Williams, T.N., Saramago Goncalves, P., George, E.C., Gibb, D.M., Walker, A.S; TRACT Group.

The New England Journal of Medicine. 2019. 2019; : 420-431

Immediate Transfusion in African Children with Uncomplicated Severe Anemia.

Maitland, K., Kiguli, S., Olupot-Olupot, P., Engoru, C., Mallewa, M., Saramago Goncalves, P., Opoka, R.O., Mpoya, A., Alaroker, F., Nteziyaremye, J., Chagaluka, G., Kennedy, N., Nabawanuka, E., Nakuya, M., Namayanja, C., Uyoga, S., Kyeyune Byabazaire, D., M'baya, B., Wabwire, B., Frost, G., Bates, I., Evans, J.A., Williams, T.N., George, E.C., Gibb, D.M., Walker, A.S.; TRACT Group.

The New England Journal of Medicine. 2019. 2019; : 407-419

Mortality after fluid bolus in African children with severe infection

Maitland, K., Kiguli, S., Opoka, R. O., Engoru, C., Olupot-Olupot, P., Akech, S. O., Nyeko, R., Mtove, G., Reyburn, H., Lang, T., Brent, B., Evans, J. A., Tibenderana, J. K., Crawley, J., Russell, E. C., Levin, M., Babiker, A. G., Gibb, D. M.

N Engl J Med. 2011; : 2483-95

Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial

Maitland, K., George, E. C., Evans, J. A., Kiguli, S., Olupot-Olupot, P., Akech, S. O., Opoka, R. O., Engoru, C., Nyeko, R., Mtove, G., Reyburn, H., Brent, B., Nteziyaremye, J., Mpoya, A., Prevatt, N., Dambisya, C. M., Semakula, D., Ddungu, A., Okuuny, V., Wokulira, R., Timbwa, M., Otii, B., Levin, M., Crawley, J., Babiker, A. G., Gibb, D. M.

BMC Med. 2013; : 68

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