Prof. Kathryn Maitland

Principal Investigator

kathryn.maitland@gmail.com

Biography

Professor of Paediatric Tropical Infectious Diseases at the Faculty of Medicine and Director of the ICCARE Centre at the Global Centre of Health Innovation, Imperial College, London and an Honorary Fellow at MRC Clinical Trials Unit, University College, London. Over the last 20 years she has been based full-time at the East Africa, where she leads a research group that have highlighted the unique importance of emergency-care research as a highly targeted and cost-effective means of tackling childhood mortality in resource-limited sub-Saharan Africa hospitals. Her team conducted the largest trial in critically children ever undertaken in Africa (FEAST trial) examining fluid resuscitation strategies in children with severe febrile illness, showing that fluid boluses increased mortality. Her team has recently completed Phase III factorial trial of transfusion and other treatment strategies in 4000 African children with severe life-threatening anaemia (TRACT)

Current Work

Her major research portfolio includes severe malaria, bacterial sepsis and severe malnutrition. She is now leading the COAST (Children’s Oxygenation Administration Strategies Trial) investigating who needs oxygen and how best to administer it in 4200 children. Through a collaborative award in science from Wellcome in 2018 she will lead SMAART (A Severe Malaria Africa – A consortium for Research and Trials) consortium- a multi-disciplinary team whose membership includes world leaders in severe malaria and experts in clinical trials. The overarching aim of SMAART is to improve outcomes from severe malaria in African children by conducting a umbrella trial, investigating multiple interventions in parallel, to enable evidence-based updates of treatment guidelines for severe malaria.

Top 5 Publications

Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial

Mpoya, A., Kiguli, S., Olupot-Olupot, P., Opoka, R. O., Engoru, C., Mallewa, M., Chimalizeni, Y., Kennedy, N., Kyeyune, D., Wabwire, B., M’Baya, B., Bates, I., Urban, B., von Hensbroek, M. B., Heyderman, R., Thomason, M. J., Uyoga, S., Williams, T. N., Gibb, D. M., George, E. C., Walker, A. S., Maitland, K.

Trials. 2015; : 593

Mortality after fluid bolus in African children with severe infection

Maitland, K., Kiguli, S., Opoka, R. O., Engoru, C., Olupot-Olupot, P., Akech, S. O., Nyeko, R., Mtove, G., Reyburn, H., Lang, T., Brent, B., Evans, J. A., Tibenderana, J. K., Crawley, J., Russell, E. C., Levin, M., Babiker, A. G., Gibb, D. M.

N Engl J Med. 2011; : 2483-95

The FEAST trial of fluid bolus in African children with severe infection

Maitland, K., Babiker, A., Kiguli, S., Molyneux, E.

Lancet. 2012; : 613; author reply 613-4

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

Dondorp, A. M., Fanello, C. I., Hendriksen, I. C., Gomes, E., Seni, A., Chhaganlal, K. D., Bojang, K., Olaosebikan, R., Anunobi, N., Maitland, K., Kivaya, E., Agbenyega, T., Nguah, S. B., Evans, J., Gesase, S., Kahabuka, C., Mtove, G., Nadjm, B., Deen, J., Mwanga-Amumpaire, J., Nansumba, M., Karema, C., Umulisa, N., Uwimana, A., Mokuolu, O. A., Adedoyin, O. T., Johnson, W. B., Tshefu, A. K., Onyamboko, M. A., Sakulthaew, T., Ngum, W. P., Silamut, K., Stepniewska, K., Woodrow, C. J., Bethell, D., Wills, B., Oneko, M., Peto, T. E., von Seidlein, L., Day, N. P., White, N. J.

Lancet. 2010; : 1647-57

Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial

Maitland, K., George, E. C., Evans, J. A., Kiguli, S., Olupot-Olupot, P., Akech, S. O., Opoka, R. O., Engoru, C., Nyeko, R., Mtove, G., Reyburn, H., Brent, B., Nteziyaremye, J., Mpoya, A., Prevatt, N., Dambisya, C. M., Semakula, D., Ddungu, A., Okuuny, V., Wokulira, R., Timbwa, M., Otii, B., Levin, M., Crawley, J., Babiker, A. G., Gibb, D. M.

BMC Med. 2013; : 68

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