Akech S

Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.Schilling WHK, Mukaka M, Callery JJ, Llewelyn MJ, Cruz CV, Dhorda M, Ngernseng T, Waithira N, Ekkapongpisit M, Watson JA, Chandna A, Nelwan EJ, Hamers RL, Etyang A, Beg MA, Sow S, Yavo W, Allabi AC, Basnyat B, Sharma SK, Amofa-Sekyi M, Yonga P, Adler A, Yuentrakul P, Cope T, Thaipadungpanit J, Rienpradub P, Imwong M, Abdad MY, Blacksell SD, Tarning J, Goudjo FF, Dossou AD, Konaté-Touré A, Assi SB, Ouffoué K, Nasronudin N, Rachman BE, Romadhon PZ, Dewanto DD, Heryana MO, Novi T, Pasaribu AP, Mutiara M, Nasution MPR, Khairunnisa K, Dalimunthe FA, Airlangga E, Fahrezzy A, Subronto Y, Ananda NR, Rahardjani M, Rimainar A, Lucinde RK, Timbwa M, Onyango OE, Agutu C, Akech S, Hamaluba M, Kipyego J, Ngachi O, Haidara FC, Traoré OY, Diarra F, Khanal B, Dahal P, Shrestha S, Rijal S, Kabore Y, Adehossi E, Guindo O, Qamar FN, Kazi AM, Woodrow CJ, Laird S, Cheeba M, Ayles H, Cheah PY, Taylor WRJ, Batty EM, Chotivanich K, Pukrittayakamee S, Phumratanaprapin W, von Seidlein L, Dondorp A, Day NPJ, White NJ
PLoS Med, (2024). 21:e1004428

Comparison between the Smart Triage model and the Emergency Triage Assessment and Treatment guidelines in triaging children presenting to the emergency departments of two public hospitals in Kenya.Kamau S, Kigo J, Mwaniki P, Dunsmuir D, Pillay Y, Zhang C, Nyamwaya B, Kimutai D, Ouma M, Mohammed I, Gachuhi K, Chege M, Thuranira L, Ansermino JM, Akech S
PLOS Digit Health, (2024). 3:e0000408

Geographical validation of the Smart Triage Model by age group.Zhang C, Wiens MO, Dunsmuir D, Pillay Y, Huxford C, Kimutai D, Tenywa E, Ouma M, Kigo J, Kamau S, Chege M, Kenya-Mugisha N, Mwaka S, Dumont GA, Kissoon N, Akech S, Ansermino JM
PLOS Digit Health, (2024). 3:e0000311

External validation of a paediatric Smart triage model for use in resource limited facilities.Kigo J, Kamau S, Mawji A, Mwaniki P, Dunsmuir D, Pillay Y, Zhang C, Pallot K, Ogero M, Kimutai D, Ouma M, Mohamed I, Chege M, Thuranira L, Kissoon N, Ansermino JM, Akech S
PLOS Digit Health, (2024). 3:e0000293

Severe outcomes of malaria in children under time-varying exposure.De Salazar PM, Kamau A, Cavelan A, Akech S, Mpimbaza A, Snow RW, Penny MA
Nat Commun, (2024). 15:4069

Feasibility, safety, and impact of the RTS,S/AS01(E) malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi.Asante KP, Mathanga DP, Milligan P, Akech S, Oduro A, Mwapasa V, Moore KA, Kwambai TK, Hamel MJ, Gyan T, Westercamp N, Kapito-Tembo A, Njuguna P, Ansong D, Kariuki S, Mvalo T, Snell P, Schellenberg D, Welega P, Otieno L, Chimala A, Afari EA, Bejon P, Maleta K, Agbenyega T, Snow RW, Zulu M, Chinkhumba J, Samuels AM
Lancet, (2024). 403:1660-1670

Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock.Sanchez-Pinto LN, Bennett TD, DeWitt PE, Russell S, Rebull MN, Martin B, Akech S, Albers DJ, Alpern ER, Balamuth F, Bembea M, Chisti MJ, Evans I, Horvat CM, Jaramillo-Bustamante JC, Kissoon N, Menon K, Scott HF, Weiss SL, Wiens MO, Zimmerman JJ, Argent AC, Sorce LR, Schlapbach LJ, Watson RS, Society of Critical Care Medicine Pediatric Sepsis Definition Task Force, Biban P, Carrol E, Chiotos K, Flauzino De Oliveira C, Hall MW, Inwald D, Ishimine P, Levin M, Lodha R, Nadel S, Nakagawa S, Peters MJ, Randolph AG, Ranjit S, Souza DC, Tissieres P, Wynn JL
JAMA, (2024). 331:675-686

International Consensus Criteria for Pediatric Sepsis and Septic Shock.Schlapbach LJ, Watson RS, Sorce LR, Argent AC, Menon K, Hall MW, Akech S, Albers DJ, Alpern ER, Balamuth F, Bembea M, Biban P, Carrol ED, Chiotos K, Chisti MJ, DeWitt PE, Evans I, Flauzino de Oliveira C, Horvat CM, Inwald D, Ishimine P, Jaramillo-Bustamante JC, Levin M, Lodha R, Martin B, Nadel S, Nakagawa S, Peters MJ, Randolph AG, Ranjit S, Rebull MN, Russell S, Scott HF, de Souza DC, Tissieres P, Weiss SL, Wiens MO, Wynn JL, Kissoon N, Zimmerman JJ, Sanchez-Pinto LN, Bennett TD, Society of Critical Care Medicine Pediatric Sepsis Definition Task Force
JAMA, (2024). 331:665-674

Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda.Knappett M, Hooft A, Maqsood MB, Lavoie PM, Kortz T, Mehta S, Duby J, Akech S, Maina M, Carter R, Popescu CR, Daftary R, Mugisha NK, Mwesigwa D, Kabakyenga J, Kumbakumba E, Ansermino JM, Kissoon N, Mutekanga A, Hau D, Moschovis P, Kangwa M, Chen C, Firnberg M, Glomb N, Argent A, Reid SJ, Bhutta A, Wiens MO
Pediatrics, (2023). 152:e2023062011

Pediatric prognostic models predicting inhospital child mortality in resource-limited settings: An external validation study.Ogero M, Ndiritu J, Sarguta R, Tuti T, Akech S
Health Sci Rep, (2023). 6:e1433

Using self-supervised feature learning to improve the use of pulse oximeter signals to predict paediatric hospitalization.Mwaniki P, Kamanu T, Akech S, Dunsmuir D, Ansermino JM, Eijkemans MJC
Wellcome Open Res, (2023). 6:248

Recalibrating prognostic models to improve predictions of in-hospital child mortality in resource-limited settings.Ogero M, Ndiritu J, Sarguta R, Tuti T, Aluvaala J, Akech S
Paediatr Perinat Epidemiol, (2023). 37:313-321

Tackling post-discharge mortality in children living in LMICs to reduce child deaths.Akech S, Kwambai T, Wiens MO, Chandna A, Berkley JA, Snow RW
Lancet Child Adolesc Health, (2023). 7:149-151

The CINAMR (Clinical Information Network-Antimicrobial Resistance) Project: A pilot microbial surveillance using hospitals linked to regional laboratories in Kenya: Study Protocol.Akech S, Nyamwaya B, Gachoki J, Ogero M, Kigo J, Maina M, Mutua E, Ooko E, Bejon P, Mwarumba S, Bahati F, Mvera B, Musyimi R, Onsare R, Hutter J, Tanui E, Wesangula E, Turner P, Dunachie S, Lucey O, McKnight J
Wellcome Open Res, (2022). 7:256

Malaria hospitalisation in East Africa: age, phenotype and transmission intensity.Kamau A, Paton RS, Akech S, Mpimbaza A, Khazenzi C, Ogero M, Mumo E, Alegana VA, Agweyu A, Mturi N, Mohammed S, Bigogo G, Audi A, Kapisi J, Sserwanga A, Namuganga JF, Kariuki S, Otieno NA, Nyawanda BO, Olotu A, Salim N, Athuman T, Abdulla S, Mohamed AF, Mtove G, Reyburn H, Gupta S, Lourenco J, Bejon P, Snow RW
BMC Med, (2022). 20:28

Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Menon K, Schlapbach LJ, Akech S, Argent A, Biban P, Carrol ED, Chiotos K, Jobayer Chisti M, Evans IVR, Inwald DP, Ishimine P, Kissoon N, Lodha R, Nadel S, Oliveira CF, Peters M, Sadeghirad B, Scott HF, de Souza DC, Tissieres P, Watson RS, Wiens MO, Wynn JL, Zimmerman JJ, Sorce LR, Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine
Crit Care Med, (2022). 50:21-36

Pulse oximetry adoption and oxygen orders at paediatric admission over 7 years in Kenya: a multihospital retrospective cohort study.Tuti T, Aluvaala J, Akech S, Agweyu A, Irimu G, English M, Clinical Information Network Author Group
BMJ Open, (2021). 11:e050995

Malaria infection and severe disease risks in Africa.Paton RS, Kamau A, Akech S, Agweyu A, Ogero M, Mwandawiro C, Mturi N, Mohammed S, Mpimbaza A, Kariuki S, Otieno NA, Nyawanda BO, Mohamed AF, Mtove G, Reyburn H, Gupta S, Bejon P, Lourenço J, Snow RW
Science, (2021). 373:926-931

Prevalence and fluid management of dehydration in children without diarrhoea admitted to Kenyan hospitals: a multisite observational study.Omoke S, English M, Aluvaala J, Gathara D, Agweyu A, Akech S, Clinical Information Network
BMJ Open, (2021). 11:e042079

Surveillance strategies using routine microbiology for antimicrobial resistance in low- and middle-income countries.Lim C, Ashley EA, Hamers RL, Turner P, Kesteman T, Akech S, Corso A, Mayxay M, Okeke IN, Limmathurotsakul D, van Doorn HR
Clin Microbiol Infect, (2021). 27:1391-1399