Publications

Epidemiology and Demography

Modifying Intestinal Integrity and Micro Biome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial.Walsh, K. Calder, N. Olupot-Olupot, P. Ssenyondo, T. Okiror, W. Okalebo, C. B. Muhindo, R. Mpoya, A. Holmes, E. Marchesi, J. Delamare de la Villenaise de Chenevarin, G. Frost, G. Maitland, K.
Wellcome Open Res, (2018). 3:95

Whole genome analysis of local Kenyan and global sequences unravels the epidemiological and molecular evolutionary dynamics of RSV genotype ON1 strains.Otieno, J. R. Kamau, E. M. Oketch, J. W. Ngoi, J. M. Gichuki, A. M. Binter, S. Otieno, G. P. Ngama, M. Agoti, C. N. Cane, P. A. Kellam, P. Cotten, M. Lemey, P. Nokes, D. J.
Virus Evol, (2018). 4:vey027

Untargeted analysis of the airway proteomes of children with respiratory infections using mass spectrometry based proteomics.Sande, C. J. Mutunga, M. Muteti, J. Berkley, J. A. Nokes, D. J. Njunge, J.
Sci Rep, (2018). 8:13814

Surveillance of respiratory viruses in the outpatient setting in rural coastal Kenya: baseline epidemiological observations.Nyiro, J. U. Munywoki, P. Kamau, E. Agoti, C. Gichuki, A. Etyang, T. Otieno, G. Nokes, D. J.
Wellcome Open Res, (2018). 3:89

Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children.Morpeth, S. C. Munywoki, P. Hammitt, L. L. Bett, A. Bottomley, C. Onyango, C. O. Murdoch, D. R. Nokes, D. J. Scott, J. A. G.
Sci Rep, (2018). 8:11030

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.Ndila, C. M. Uyoga, S. Macharia, A. W. Nyutu, G. Peshu, N. Ojal, J. Shebe, M. Awuondo, K. O. Mturi, N. Tsofa, B. Sepulveda, N. Clark, T. G. Band, G. Clarke, G. Rowlands, K. Hubbart, C. Jeffreys, A. Kariuki, S. Marsh, K. Mackinnon, M. Maitland, K. Kwiatkowski, D. P. Rockett, K. A. Williams, T. N. Malaria, G. E. N. Consortium
Lancet Haematol, (2018). 5:e333-e345

Risk factors for mortality and effect of correct fluid prescription in children with diarrhoea and dehydration without severe acute malnutrition admitted to Kenyan hospitals: an observational, association study.Akech, S. Ayieko, P. Gathara, D. Agweyu, A. Irimu, G. Stepniewska, K. English, M. Clinical Information Network, authors
Lancet Child Adolesc Health, (2018). 2:516-524

Caregiver oral rehydration solution fluid monitoring charts versus standard care for the management of some dehydration among Kenyan children: a randomized controlled trial.Kailemia, M. Kariuki, N. Laving, A. Agweyu, A. Wamalwa, D.
Int Health, (2018). 10:442-450

Prevalence, outcome and quality of care among children hospitalized with severe acute malnutrition in Kenyan hospitals: A multi-site observational study.Gachau, S. Irimu, G. Ayieko, P. Akech, S. Agweyu, A. English, M. Clinical Information Network Author, Group
PLoS One, (2018). 13:e0197607

Human Coronavirus NL63 Molecular Epidemiology and Evolutionary Patterns in Rural Coastal Kenya.Kiyuka, P. K. Agoti, C. N. Munywoki, P. K. Njeru, R. Bett, A. Otieno, J. R. Otieno, G. P. Kamau, E. Clark, T. G. van der Hoek, L. Kellam, P. Nokes, D. J. Cotten, M.
J Infect Dis, (2018). 217:1728-1739

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia.Opi, D. H. Swann, O. Macharia, A. Uyoga, S. Band, G. Ndila, C. M. Harrison, E. M. Thera, M. A. Kone, A. K. Diallo, D. A. Doumbo, O. K. Lyke, K. E. Plowe, C. V. Moulds, J. M. Shebbe, M. Mturi, N. Peshu, N. Maitland, K. Raza, A. Kwiatkowski, D. P. Rockett, K. A. Williams, T. N. Rowe, J. A.
Elife, (2018). 7:

Continuous Invasion by Respiratory Viruses Observed in Rural Households During a Respiratory Syncytial Virus Seasonal Outbreak in Coastal Kenya.Munywoki, P. K. Koech, D. C. Agoti, C. N. Cane, P. A. Medley, G. F. Nokes, D. J.
Clin Infect Dis, (2018). 67:1559-1567

Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial.Mallewa, J. Szubert, A. J. Mugyenyi, P. Chidziva, E. Thomason, M. J. Chepkorir, P. Abongomera, G. Baleeta, K. Etyang, A. Warambwa, C. Melly, B. Mudzingwa, S. Kelly, C. Agutu, C. Wilkes, H. Nkomani, S. Musiime, V. Lugemwa, A. Pett, S. L. Bwakura-Dangarembizi, M. Prendergast, A. J. Gibb, D. M. Walker, A. S. Berkley, J. A. Reality trial team
Lancet HIV, (2018). 5:e231-e240

Sickle Cell Anemia and Its Phenotypes.Williams, T. N. Thein, S. L.
Annu Rev Genomics Hum Genet, (2018). 19:113-147

Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children.Gilchrist, J. J. Mentzer, A. J. Rautanen, A. Pirinen, M. Mwarumba, S. Njuguna, P. Mturi, N. Wellcome Trust Case-Control, Consortium Kenyan Bacteraemia Study, Group Williams, T. N. Scott, J. A. G. Hill, A. V. S.
Proc Natl Acad Sci U S A, (2018). 115:E3601-E3603

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.Gilchrist, J. J. Rautanen, A. Fairfax, B. P. Mills, T. C. Naranbhai, V. Trochet, H. Pirinen, M. Muthumbi, E. Mwarumba, S. Njuguna, P. Mturi, N. Msefula, C. L. Gondwe, E. N. MacLennan, J. M. Chapman, S. J. Molyneux, M. E. Knight, J. C. Spencer, C. C. A. Williams, T. N. MacLennan, C. A. Scott, J. A. G. Hill, A. V. S.
Nat Commun, (2018). 9:1014

Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa.Aramburo, A. Todd, J. George, E. C. Kiguli, S. Olupot-Olupot, P. Opoka, R. O. Engoru, C. Akech, S. O. Nyeko, R. Mtove, G. Gibb, D. M. Babiker, A. G. Maitland, K.
BMC Med, (2018). 16:37

Approaching quality improvement at scale: a learning health system approach in Kenya.Irimu, G. Ogero, M. Mbevi, G. Agweyu, A. Akech, S. Julius, T. Nyamai, R. Githang'a, D. Ayieko, P. English, M. Clinical Information Network Authors, Group
Arch Dis Child, (2018). 103:1013-1019

Prospective Observational Study of Incidence and Preventable Burden of Childhood Tuberculosis, Kenya.Brent, A. J. Nyundo, C. Langat, J. Mulunda, C. Wambua, J. Bauni, E. Sande, J. Park, K. Williams, T. N. Newton, C. R. J. Levin, M. Scott, J. A. G. Kids Tb Study Group
Emerg Infect Dis, (2018). 24:514-523

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.Taylor, W. R. Naw, H. K. Maitland, K. Williams, T. N. Kapulu, M. D'Alessandro, U. Berkley, J. A. Bejon, P. Okebe, J. Achan, J. Amambua, A. N. Affara, M. Nwakanma, D. van Geertruyden, J. P. Mavoko, M. Lutumba, P. Matangila, J. Brasseur, P. Piola, P. Randremanana, R. Lasry, E. Fanello, C. Onyamboko, M. Schramm, B. Yah, Z. Jones, J. Fairhurst, R. M. Diakite, M. Malenga, G. Molyneux, M. Rwagacondo, C. Obonyo, C. Gadisa, E. Aseffa, A. Loolpapit, M. Henry, M. C. Dorsey, G. John, C. Sirima, S. B. Barnes, K. I. Kremsner, P. Day, N. P. White, N. J. Mukaka, M.
BMC Med, (2018). 16:11