Clinical Research

1167 results

The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum.Bejon P, Mwacharo J, Kai O, Todryk S, Keating S, Lowe B, Lang T, Mwangi TW, Gilbert SC, Peshu N, Marsh K, Hill AV
J Immunol, (2007). 179:4193-201

Defining childhood severe falciparum malaria for intervention studies.Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, Maitland K, Williams T, Scott JA, English M, Lowe BS, Peshu N, Newton CR, Marsh K
PLoS Med, (2007). 4:e251

Extended follow-up following a phase 2b randomized trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya.Bejon P, Ogada E, Mwangi T, Milligan P, Lang T, Fegan G, Gilbert SC, Peshu N, Marsh K, Hill AV
PLoS One, (2007). 2:e707

Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus.Khor CC, Vannberg FO, Chapman SJ, Walley A, Aucan C, Loke H, White NJ, Peto T, Khor LK, Kwiatkowski D, Day N, Scott A, Berkley JA, Marsh K, Peshu N, Maitland K, Williams TN, Hill AV
Genes Immun, (2007). 8:570-6

Computerized tomography scan of the brain in a community study of neurological impairment in Kenya.Njuguna PW, Mungala-Odera V, Chong WK, Meehan RA, Newton CR
J Child Neurol, (2007). 22:26-32

'Are you on the market?': a capture-recapture enumeration of men who sell sex to men in and around Mombasa, Kenya.Geibel S, van der Elst EM, King'ola N, Luchters S, Davies A, Getambu EM, Peshu N, Graham SM, McClelland RS, Sanders EJ
AIDS, (2007). 21:1349-54

Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children.Idro R, Ndiritu M, Ogutu B, Mithwani S, Maitland K, Berkley J, Crawley J, Fegan G, Bauni E, Peshu N, Marsh K, Neville B, Newton C
JAMA, (2007). 297:2232-40

Axonal and astrocyte injury markers in the cerebrospinal fluid of Kenyan children with severe malaria.Medana IM, Idro R, Newton CR
J Neurol Sci, (2007). 258:93-8

Identifying children with neurological impairment and disability in resource-poor countries.Mung'ala-Odera V, Newton CR
Child Care Health Dev, (2007). 33:249-56

Phase III trials required to resolve clinical equipoise over optimal fluid management in children with severe malaria.Maitland K, Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Levin M, Newton CR
PLoS Clin Trials, (2007). 2:e2

Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition.Seaton C, Ignas J, Muchohi S, Kokwaro G, Maitland K, Thomson AH
J Antimicrob Chemother, (2007). 59:681-9

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O'Neill LA, Hill AV
Nat Genet, (2007). 39:523-8

Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal HIV-1 shedding.Graham SM, Holte SE, Peshu NM, Richardson BA, Panteleeff DD, Jaoko WG, Ndinya-Achola JO, Mandaliya KN, Overbaugh JM, McClelland RS
AIDS, (2007). 21:501-7

Investigating the utility of the HIV-1 BED capture enzyme immunoassay using cross-sectional and longitudinal seroconverter specimens from Africa.Karita E, Price M, Hunter E, Chomba E, Allen S, Fei L, Kamali A, Sanders EJ, Anzala O, Katende M, Ketter N
AIDS, (2007). 21:403-8

Elevated plasma urokinase receptor predicts low birth weight in maternal malaria.Ostrowski SR, Shulman CE, Peshu N, Staalsoe T, Hoyer-Hansen G, Pedersen BK, Marsh K, Ullum H
Parasite Immunol, (2007). 29:37-46

A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya.Bejon P, Mwacharo J, Kai O, Mwangi T, Milligan P, Todryk S, Keating S, Lang T, Lowe B, Gikonyo C, Molyneux C, Fegan G, Gilbert SC, Peshu N, Marsh K, Hill AV
PLoS Clin Trials, (2006). 1:e29

Medical informatics in medical research - the Severe Malaria in African Children (SMAC) Network's experience.Olola CH, Missinou MA, Issifou S, Anane-Sarpong E, Abubakar I, Gandi JN, Chagomerana M, Pinder M, Agbenyega T, Kremsner PG, Newton CR, Wypij D, Taylor TE
Methods Inf Med, (2006). 45:483-91

Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial.Akech S, Gwer S, Idro R, Fegan G, Eziefula AC, Newton CR, Levin M, Maitland K
PLoS Clin Trials, (2006). 1:e21

Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naive and malaria-exposed individuals.Bejon P, Keating S, Mwacharo J, Kai OK, Dunachie S, Walther M, Berthoud T, Lang T, Epstein J, Carucci D, Moris P, Cohen J, Gilbert SC, Peshu N, Marsh K, Hill AV
Infect Immun, (2006). 74:6331-8

The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standard.Ochola LB, Vounatsou P, Smith T, Mabaso ML, Newton CR
Lancet Infect Dis, (2006). 6:582-8