Sera from 94 patients infected with human immunodeficiency virus (HIV) 1, together with 86 controls, attending the Kenyatta National Hospital, Nairobi were examined for antibodies to Toxoplasma gondii using enzyme immunoassay and latex and dye tests. 54% had Toxoplasma-specific immunoglobulin G (IgG) by dye test. 22% of the HIV-positive group had IgG levels in excess of 180 units/ml (approximating to a dye test titre of 1:1300) compared to 1% of the HIV-negative group. There was no correlation between high levels of IgG and clinical stage of HIV disease or features indicative of active toxoplasmosis. It is proposed that the elevated serum IgG is a reflection of early Toxoplasma reactivation, not necessarily associated with disease.
Brindle, R., Holliman, R., Gilks, C., Waiyaki, P.