Tom Williams

Filling the data gaps on sickle cell anaemia in sub-Saharan Africa.Williams TN
Lancet Haematol, (2022). 9:e172-e173

Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial.George EC, Uyoga S, M'Baya B, Kyeyune Byabazair D, Kiguli S, Olupot-Olupot P, Opoka RO, Chagaluka G, Alaroker F, Williams TN, Bates I, Mbanya D, Gibb DM, Walker AS, Maitland K, Tract trial study group
Lancet Glob Health, (2022). 10:e360-e368

A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa.Olupot-Olupot P, Connon R, Kiguli S, Opoka RO, Alaroker F, Uyoga S, Nakuya M, Okiror W, Nteziyaremye J, Ssenyondo T, Nabawanuka E, Kayaga J, Williams Mukisa C, Amorut D, Muhindo R, Frost G, Walsh K, Macharia AW, Gibb DM, Walker AS, George EC, Maitland K, Williams TN
Am J Hematol, (2022). 97:527-536

Malaria protection due to sickle haemoglobin depends on parasite genotype.Band G, Leffler EM, Jallow M, Sisay-Joof F, Ndila CM, Macharia AW, Hubbart C, Jeffreys AE, Rowlands K, Nguyen T, Goncalves S, Ariani CV, Stalker J, Pearson RD, Amato R, Drury E, Sirugo G, d'Alessandro U, Bojang KA, Marsh K, Peshu N, Saelens JW, Diakite M, Taylor SM, Conway DJ, Williams TN, Rockett KA, Kwiatkowski DP
Nature, (2022). 602:106-111

Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia.Abuga KM, Muriuki JM, Uyoga SM, Mwai K, Makale J, Mogire RM, Macharia AW, Mohammed S, Muthumbi E, Mwarumba S, Mturi N, Bejon P, Scott JAG, Nairz M, Williams TN, Atkinson SH
Haematologica, (2022). 107:1589-1598

Risk factors of anaemia and iron deficiency in Somali children and women: Findings from the 2019 Somalia Micronutrient Survey.Wirth JP, Sesay F, Mbai J, Ali SI, Donkor WES, Woodruff BA, Pilane Z, Mohamud KM, Muse A, Yussuf HO, Mohamed WS, Veraguth R, Rezzi S, Williams TN, Mohamoud AM, Mohamud FM, Galvin M, Rohner F, Katambo Y, Petry N
Matern Child Nutr, (2022). 18:e13254

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.Olupot-Olupot P, Okiror W, Mnjalla H, Muhindo R, Uyoga S, Mpoya A, Williams TN, terHeine R, Burger DM, Urban B, Connon R, George EC, Gibb DM, Walker AS, Maitland K
Wellcome Open Res, (2021). 6:161

Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.Kiguli S, Olopot-Olupot P, Alaroker F, Engoru C, Opoka RO, Tagoola A, Hamaluba M, Mnjalla H, Mpoya A, Mogaka C, Nalwanga D, Nabawanuka E, Nokes J, Nyaigoti C, Briend A, van Woensel JBM, Grieve R, Sadique Z, Williams TN, Thomas K, Harrison DA, Rowan K, Maitland K
Wellcome Open Res, (2021). 6:221

Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data.Connon R, George EC, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Nabawanuka E, Sennyondo T, Amorut D, Williams Musika C, Bates I, Boele van Hensbroek M, Evans JA, Uyoga S, Williams TN, Frost G, Gibb DM, Maitland K, Walker AS, Tract trial group
BMC Public Health, (2021). 21:1480

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision.Watson JA, Ndila CM, Uyoga S, Macharia A, Nyutu G, Mohammed S, Ngetsa C, Mturi N, Peshu N, Tsofa B, Rockett K, Leopold S, Kingston H, George EC, Maitland K, Day NP, Dondorp AM, Bejon P, Williams TN, Holmes CC, White NJ
Elife, (2021). 10:69698

Prevalence and predictors of vitamin D deficiency in young African children.Mogire RM, Morovat A, Muriuki JM, Mentzer AJ, Webb EL, Kimita W, Ndungu FM, Macharia AW, Cutland CL, Sirima SB, Diarra A, Tiono AB, Lule SA, Madhi SA, Sandhu MS, Prentice AM, Bejon P, Pettifor JM, Elliott AM, Adeyemo A, Williams TN, Atkinson SH
BMC Med, (2021). 19:115

Transfusion management of severe anaemia in African children: a consensus algorithm.Maitland K, Kiguli S, Olupot-Olupot P, Opoka RO, Chimalizeni Y, Alaroker F, Uyoga S, Kyeyune-Byabazaire D, M'Baya B, Bates I, Williams TN, Munube D, Mbanya D, Molyneux EM, South A, Walker AS, Gibb DM, George EC, Tract Stakeholders meeting group
Br J Haematol, (2021). 193:1247-1259

Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia.Maitland K, Kiguli S, Olupot-Olupot P, Hamaluba M, Thomas K, Alaroker F, Opoka RO, Tagoola A, Bandika V, Mpoya A, Mnjella H, Nabawanuka E, Okiror W, Nakuya M, Aromut D, Engoru C, Oguda E, Williams TN, Fraser JF, Harrison DA, Rowan K, Coast trial group
Intensive Care Med, (2021). 47:566-576

Malaria is a cause of iron deficiency in African children.Muriuki JM, Mentzer AJ, Mitchell R, Webb EL, Etyang AO, Kyobutungi C, Morovat A, Kimita W, Ndungu FM, Macharia AW, Ngetsa CJ, Makale J, Lule SA, Musani SK, Raffield LM, Cutland CL, Sirima SB, Diarra A, Tiono AB, Fried M, Gwamaka M, Adu-Afarwuah S, Wirth JP, Wegmuller R, Madhi SA, Snow RW, Hill AVS, Rockett KA, Sandhu MS, Kwiatkowski DP, Prentice AM, Byrd KA, Ndjebayi A, Stewart CP, Engle-Stone R, Green TJ, Karakochuk CD, Suchdev PS, Bejon P, Duffy PE, Davey Smith G, Elliott AM, Williams TN, Atkinson SH
Nat Med, (2021). 27:653-658

Undernutrition: a major but potentially preventable cause of poor outcomes in children living with sickle cell disease in Africa.Williams TN
BMC Med, (2021). 19:17

Risk factors for anaemia among Ghanaian women and children vary by population group and climate zone.Petry N, Wirth JP, Adu-Afarwuah S, Wegmuller R, Woodruff BA, Tanumihardjo SA, Bentil H, Donkor WES, Williams TN, Shahab-Ferdows S, Selenje L, Mahama A, Steiner-Asiedu M, Rohner F
Matern Child Nutr, (2021). 17:e13076

Plasma Plasmodium falciparum Histidine-rich Protein 2 Concentrations in Children With Malaria Infections of Differing Severity in Kilifi, Kenya.Uyoga S, Wanjiku P, Rop JC, Makale J, Macharia AW, Nyutu GM, Shebe M, Awuondo KA, Mturi N, Woodrow CJ, Dondorp AM, Maitland K, Williams TN
Clin Infect Dis, (2021). 73:e2415-e2423

Iron Deficiency Is Associated With Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children.Bundi CK, Nalwoga A, Lubyayi L, Muriuki JM, Mogire RM, Opi H, Mentzer AJ, Mugyenyi CK, Mwacharo J, Webb EL, Bejon P, Williams TN, Gikunju JK, Beeson JG, Elliott AM, Ndungu FM, Atkinson SH
Clin Infect Dis, (2021). 73:43-49

All-cause and cause-specific mortality in Kilifi Health and Demographic Surveillance System, in Kenya in the period of the COVID-19 pandemic..Otiende M, Nyagura A, Bottomley C, Walumbe D, Mochama G, Amadi D, Nyundo C, Kagucia W, Etyang AO, Adetifa IMO, Maitha E, Chondo E, Nzomo E, Aman R, Mwangangi M, Amoth P, Wangari N, Barasa E, Mwangangi J, Bejon P, Agweyu A, Williams TN, Scott JAG
1st International Conference on Public Health in Africa (CPHIA), (2021). :

Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the alpha (3.7I) form of alpha-thalassaemia using genome-wide microarray data.Ndila CM, Nyirongo V, Macharia AW, Jeffreys AE, Rowlands K, Hubbart C, Busby GBJ, Band G, Harding RM, Rockett KA, Williams TN, Malaria GENConsortium
Wellcome Open Res, (2020). 5:287