Francis Ndungu

Repeated clinical malaria episodes are associated with modification of the immune system in children.Bediako Y, Adams R, Reid AJ, Valletta JJ, Ndungu FM, Sodenkamp J, Mwacharo J, Ngoi JM, Kimani D, Kai O, Wambua J, Nyangweso G, de Villiers EP, Sanders M, Lotkowska ME, Lin JW, Manni S, Addy JWG, Recker M, Newbold C, Berriman M, Bejon P, Marsh K, Langhorne J
BMC Med, (2019). 17:60

Longitudinal Analysis of Infant Stool Bacteria Communities Before and After Acute Febrile Malaria and Artemether-Lumefantrine Treatment.Mandal RK, Crane RJ, Berkley JA, Gumbi W, Wambua J, Ngoi JM, Ndungu FM, Schmidt NW
J Infect Dis, (2019). 220:687-698

Transmission and Age Impact the Risk of Developing Febrile Malaria in Children with Asymptomatic Plasmodium falciparum Parasitemia.Wamae K, Wambua J, Nyangweso G, Mwambingu G, Osier F, Ndung'u F, Bejon P, Ochola-Oyier LI
J Infect Dis, (2019). 219:936-944

Iron Status and Associated Malaria Risk Among African Children.Muriuki JM, Mentzer AJ, Kimita W, Ndungu FM, Macharia AW, Webb EL, Lule SA, Morovat A, Hill AVS, Bejon P, Elliott AM, Williams TN, Atkinson SH
Clin Infect Dis, (2019). 68:1807-1814

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study.Huttner A, Agnandji ST, Combescure C, Fernandes JF, Bache EB, Kabwende L, Ndungu FM, Brosnahan J, Monath TP, Lemaitre B, Grillet S, Botto M, Engler O, Portmann J, Siegrist D, Bejon P, Silvera P, Kremsner P, Siegrist CA, VEBCON, VSV-EBOVAC, VSV-EBOPLUS Consortia
Lancet Infect Dis, (2018). 18:738-748

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.Pieper K, Tan J, Piccoli L, Foglierini M, Barbieri S, Chen Y, Silacci-Fregni C, Wolf T, Jarrossay D, Anderle M, Abdi A, Ndungu FM, Doumbo OK, Traore B, Tran TM, Jongo S, Zenklusen I, Crompton PD, Daubenberger C, Bull PC, Sallusto F, Lanzavecchia A
Nature, (2017). 548:597-601

The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum - an epidemiological "natural experiment".Bediako Y, Ngoi JM, Nyangweso G, Wambua J, Opiyo M, Nduati EW, Bejon P, Marsh K, Ndungu FM
BMC Med, (2016). 14:143

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.Tan J, Pieper K, Piccoli L, Abdi A, Perez MF, Geiger R, Tully CM, Jarrossay D, Maina Ndungu F, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A
Nature, (2016). 529:105-109

Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models.Ndungu FM, Marsh K, Fegan G, Wambua J, Nyangweso G, Ogada E, Mwangi T, Nyundo C, Macharia A, Uyoga S, Williams TN, Bejon P
BMC Med, (2015). 13:183

Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children.Olotu A, Clement F, Jongert E, Vekemans J, Njuguna P, Ndungu FM, Marsh K, Leroux-Roels G, Bejon P
PLoS One, (2014). 9:e115126

Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion.Illingworth J, Butler NS, Roetynck S, Mwacharo J, Pierce SK, Bejon P, Crompton PD, Marsh K, Ndungu FM
J Immunol, (2013). 190:1038-47

Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.Ibison F, Olotu A, Muema DM, Mwacharo J, Ohuma E, Kimani D, Marsh K, Bejon P, Ndungu FM
PLoS One, (2012). 7:e52939

A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E.Ndungu FM, Mwacharo J, Kimani D, Kai O, Moris P, Jongert E, Vekemans J, Olotu A, Bejon P
PLoS One, (2012). 7:e52870

Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children.Ndungu FM, Olotu A, Mwacharo J, Nyonda M, Apfeld J, Mramba LK, Fegan GW, Bejon P, Marsh K
Proc Natl Acad Sci U S A, (2012). 109:8247-52

High efficiency human memory B cell assay and its application to studying Plasmodium falciparum-specific memory B cells in natural infections.Weiss GE, Ndungu FM, McKittrick N, Li S, Kimani D, Crompton PD, Marsh K, Pierce SK
J Immunol Methods, (2012). 375:68-74

Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study.Muema DK, Ndungu FM, Kinyanjui SM, Berkley JA
Malar J, (2011). 10:55

Apicomplexa: Malaria.Lamb TJ, Ndungu FM
Immunity to Parasitic Infections, (2011). :

Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice.Nduati EW, Ng DH, Ndungu FM, Gardner P, Urban BC, Langhorne J
PLoS One, (2010). 5:e15007

Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells.Stephens R, Ndungu FM, Langhorne J
Parasite Immunol, (2009). 31:20-31

Immunity to malaria: more questions than answers.Langhorne J, Ndungu FM, Sponaas AM, Marsh K
Nat Immunol, (2008). 9:725-32