Williams TN

Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia.Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN, Grieve R, Sadique Z, Fraser J, Harrison D, Rowan K
Wellcome Open Res, (2017). 2:100

No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.Swann OV, Harrison EM, Opi DH, Nyatichi E, Macharia A, Uyoga S, Williams TN, Rowe JA
Sci Rep, (2017). 7:17825

Subphenotypes of sickle cell disease in Africa.Piel FB, Williams TN
Blood, (2017). 130:2157-2158

Detecting Malaria Hotspots: A Comparison of Rapid Diagnostic Test, Microscopy, and Polymerase Chain Reaction.Mogeni P, Williams TN, Omedo I, Kimani D, Ngoi JM, Mwacharo J, Morter R, Nyundo C, Wambua J, Nyangweso G, Kapulu M, Fegan G, Bejon P
J Infect Dis, (2017). 216:1091-1098

Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children.Mugyenyi CK, Elliott SR, Yap XZ, Feng G, Boeuf P, Fegan G, Osier FFH, Fowkes FJI, Avril M, Williams TN, Marsh K, Beeson JG
J Infect Dis, (2017). 216:887-898

The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study.Nardo-Marino A, Williams TN, Olupot-Olupot P
BMC Hematol, (2017). 17:14

Prevalence of Inherited Hemoglobin Disorders and Relationships with Anemia and Micronutrient Status among Children in Yaounde and Douala, Cameroon.Engle-Stone R, Williams TN, Nankap M, Ndjebayi A, Gimou MM, Oyono Y, Tarini A, Brown KH, Green R
Nutrients, (2017). 9:

Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa.Omedo I, Mogeni P, Bousema T, Rockett K, Amambua-Ngwa A, Oyier I, Stevenson CJ, Baidjoe AY, de Villiers EP, Fegan G, Ross A, Hubbart C, Jeffreys A, Williams TN, Kwiatkowski D, Bejon P
Wellcome Open Res, (2017). 2:10

Resistance to malaria through structural variation of red blood cell invasion receptors.Leffler EM, Band G, Busby GBJ, Kivinen K, Le QS, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Reyburn H, Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius V, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP, Malaria Genomic Epidemiology Network
Science, (2017). 356:

Blood Pressure and Arterial Stiffness in Kenyan Adolescents With alpha(+)Thalassemia.Etyang AO, Khayeka-Wandabwa C, Kapesa S, Muthumbi E, Odipo E, Wamukoya M, Ngomi N, Haregu T, Kyobutungi C, Tendwa M, Makale J, Macharia A, Cruickshank JK, Smeeth L, Scott JA, Williams TN
J Am Heart Assoc, (2017). 6:

High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda.Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R, Mtove G, Nteziyaremye J, Chebet M, George EC, Babiker AG, Gibb DM, Williams TN, Maitland K
Clin Infect Dis, (2017). 64:939-946

Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.Wang L, Ko ER, Gilchrist JJ, Pittman KJ, Rautanen A, Pirinen M, Thompson JW, Dubois LG, Langley RJ, Jaslow SL, Salinas RE, Rouse DC, Moseley MA, Mwarumba S, Njuguna P, Mturi N, Wellcome Trust Case Control Consortium, Kenyan Bacteraemia Study Group, Williams TN, Scott JA, Hill AV, Woods CW, Ginsburg GS, Tsalik EL, Ko DC
Sci Adv, (2017). 3:e1602096

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sepulveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NN, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CC, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP, Malaria GENConsortium
Elife, (2017). 6:

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance.McCallum FJ, Persson KE, Fowkes FJ, Reiling L, Mugyenyi CK, Richards JS, Simpson JA, Williams TN, Gilson PR, Hodder AN, Sanders PR, Anders RF, Narum DL, Chitnis C, Crabb BS, Marsh K, Beeson JG
J Leukoc Biol, (2017). 101:913-925

Cohort Profile: The Kilifi Vaccine Monitoring Study.Adetifa IMO, Bwanaali T, Wafula J, Mutuku A, Karia B, Makumi A, Mwatsuma P, Bauni E, Hammitt LL, Nokes DJ, Maree E, Tabu C, Kamau T, Mataza C, Williams TN, Scott JAG
Int J Epidemiol, (2017). 46:792-792h

Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study.Mogeni P, Williams TN, Fegan G, Nyundo C, Bauni E, Mwai K, Omedo I, Njuguna P, Newton CR, Osier F, Berkley JA, Hammitt LL, Lowe B, Mwambingu G, Awuondo K, Mturi N, Peshu N, Snow RW, Noor A, Marsh K, Bejon P
PLoS Med, (2016). 13:e1002047

Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.Kenyan Bacteraemia Study Group, Wellcome Trust Case Control Consortium, Rautanen A, Pirinen M, Mills TC, Rockett KA, Strange A, Ndungu AW, Naranbhai V, Gilchrist JJ, Bellenguez C, Freeman C, Band G, Bumpstead SJ, Edkins S, Giannoulatou E, Gray E, Dronov S, Hunt SE, Langford C, Pearson RD, Su Z, Vukcevic D, Macharia AW, Uyoga S, Ndila C, Mturi N, Njuguna P, Mohammed S, Berkley JA, Mwangi I, Mwarumba S, Kitsao BS, Lowe BS, Morpeth SC, Khandwalla I, Kilifi Bacteraemia Surveillance Group, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CNA, Plomin R, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Deloukas P, Peltonen L, Williams TN, Scott JAG, Chapman SJ, Donnelly P, Hill AVS, Spencer CCA
Am J Hum Genet, (2016). 98:1092-1100

Sickle Cell Disease in Sub-Saharan Africa.Williams TN
Hematol Oncol Clin North Am, (2016). 30:343-58

Red blood cell complement receptor one level varies with Knops blood group, alpha(+)thalassaemia and age among Kenyan children.Opi DH, Uyoga S, Orori EN, Williams TN, Rowe JA
Genes Immun, (2016). 17:171-8

Invasive Group A Streptococcus Infection among Children, Rural Kenya.Seale AC, Davies MR, Anampiu K, Morpeth SC, Nyongesa S, Mwarumba S, Smeesters PR, Efstratiou A, Karugutu R, Mturi N, Williams TN, Scott JA, Kariuki S, Dougan G, Berkley JA
Emerg Infect Dis, (2016). 22:224-32