edd/Wellcome Open Res

A Phase I trial of Non-invasive Ventilation and seizure prophylaxis with levetiracetam In Children with Cerebral Malaria Trial (NOVICE-M Trial).Maitland K, Obonyo N, Hamaluba M, Ogoda E, Mogaka C, Williams TN, Newton C, Kariuki SM, Gibb DM, Walker AS, Connon R, George EC
Wellcome Open Res, (2024). 9:281

SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART).Maitland K, Hamaluba M, Obonyo N, Oguda E, Mogoka C, Williams TN, Chaponda M, Miti S, Kamavu LK, Jonathan Gwasupika J, Connon R, Gibb DM, Dondorp A, Day N, White N, Walker AS, George EC
Wellcome Open Res, (2023). 8:484

Safety and immunogenicity of ChAdOx1 nCoV-19 (AZD1222) vaccine in adults in Kenya: a phase 1/2 single-blind, randomised controlled trial.Hamaluba M, Sang S, Orindi B, Njau I, Karanja H, Kamau N, Gitonga JN, Mugo D, Wright D, Nyagwange J, Kutima B, Omuoyo D, Mwatasa M, Ngetsa C, Agoti C, Cheruiyot S, Nyaguara A, Munene M, Mturi N, Oloo E, Ochola-Oyier L, Mumba N, Mauncho C, Namayi R, Davies A, Tsofa B, Nduati EW, Aliyan N, Kasera K, Etyang A, Boyd A, Hill A, Gilbert S, Douglas A, Pollard A, Bejon P, Lambe T, Warimwe G
Wellcome Open Res, (2023). 8:182

Universal iron supplementation: the best strategy to tackle childhood anaemia in malaria-endemic countries?.Karthikappallil R, Atkinson SH
Wellcome Open Res, (2023). 8:345

Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections.Abuga KM, Nairz M, MacLennan CA, Atkinson SH
Wellcome Open Res, (2023). 8:48

Assessment of gestational age at antenatal care visits among Kenyan women to inform delivery of a maternal respiratory syncytial virus (RSV) vaccine in low- and middle-income countries.Nyiro JU, Nyawanda BO, Bukusi E, Mureithi MW, Murunga N, Nokes DJ, Bigogo G, Otieno NA, Opere VA, Ouma A, Pecenka C, Munywoki PK
Wellcome Open Res, (2023). 8:154

Epidemiology of COVID-19 infections on routine polymerase chain reaction (PCR) and serology testing in Coastal Kenya.Nyagwange J, Ndwiga L, Muteru K, Wamae K, Tuju J, Testing Team C, Kutima B, Gitonga J, Karanja H, Mugo D, Kasera K, Amoth P, Murunga N, Babu L, Otieno E, Githinji G, Nokes DJ, Tsofa B, Orindi B, Barasa E, Warimwe G, Agoti CN, Bejon P, Ochola-Oyier LI
Wellcome Open Res, (2022). 7:69

Efficiency of transplacental transfer of respiratory syncytial virus (RSV) specific antibodies among pregnant women in Kenya.Nyiro JU, Bukusi E, Mwaengo D, Nyaguara A, Nyawanda B, Otieno N, Bigogo G, Murunga N, Widdowson MA, Verani JR, Chaves SS, Mwangudza H, Odundo C, Berkley JA, Nokes DJ, Munywoki PK
Wellcome Open Res, (2022). 7:43

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults).Abouyannis M, FitzGerald R, Ngama M, Mwangudzah H, Nyambura YK, Ngome S, Riako D, Babu L, Lewa F, Else L, Dily Penchala S, Orindi B, Mumba N, Kalama B, Ndungu FM, Adetifa I, Khoo S, Lalloo DG, Casewell NR, Hamaluba M
Wellcome Open Res, (2022). 7:90

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial.Olupot-Olupot P, Okiror W, Mnjalla H, Muhindo R, Uyoga S, Mpoya A, Williams TN, terHeine R, Burger DM, Urban B, Connon R, George EC, Gibb DM, Walker AS, Maitland K
Wellcome Open Res, (2021). 6:161

Revealing the extent of the first wave of the COVID-19 pandemic in Kenya based on serological and PCR-test data.Ojal J, Brand SPC, Were V, Okiro EA, Kombe IK, Mburu C, Aziza R, Ogero M, Agweyu A, Warimwe GM, Uyoga S, Adetifa IMO, Scott JAG, Otieno E, Ochola-Oyier LI, Agoti CN, Kasera K, Amoth P, Mwangangi M, Aman R, Ng'ang'a W, Tsofa B, Bejon P, Barasa E, Keeling MJ, Nokes DJ
Wellcome Open Res, (2021). 6:127

Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.Kiguli S, Olopot-Olupot P, Alaroker F, Engoru C, Opoka RO, Tagoola A, Hamaluba M, Mnjalla H, Mpoya A, Mogaka C, Nalwanga D, Nabawanuka E, Nokes J, Nyaigoti C, Briend A, van Woensel JBM, Grieve R, Sadique Z, Williams TN, Thomas K, Harrison DA, Rowan K, Maitland K
Wellcome Open Res, (2021). 6:221

Whole genome sequencing of two human rhinovirus A types (A101 and A15) detected in Kenya, 2016-2018.Luka MM, Kamau E, de Laurent ZR, Morobe JM, Alii LK, Nokes DJ, Agoti CN
Wellcome Open Res, (2021). 6:178

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol.Olupot-Olupot P, Aloroker F, Mpoya A, Mnjalla H, Passi G, Nakuya M, Houston K, Obonyo N, Hamaluba M, Evans JA, Connon R, George EC, Gibb DM, Maitland K
Wellcome Open Res, (2021). 6:160

An optimization of four SARS-CoV-2 qRT-PCR assays in a Kenyan laboratory to support the national COVID-19 rapid response teams.Mohammed KS, de Laurent ZR, Omuoyo DO, Lewa C, Gicheru E, Cheruiyot R, Bartilol B, Mutua S, Musyoki J, Gumba H, Mwacharo J, Riako D, Mwangi SJ, Gichuki BM, Nyamako L, Karani A, Karanja H, Mugo D, Gitonga JN, Njuguna S, Gumbi W, Tawa B, Tendwa M, Cheruiyot W, Sein Y, Nyambu JK, Patta SO, Thani TS, Maitha EK, Kitole B, Mwakinangu MS, Muslih BS, Otieno JO, Nyiro JU, Kiyuka P, Ndwiga L, Wamae K, Kimani D, Makale J, Morobe JM, Osoti V, Lambisia AW, Odundo C, Mwarumba S, Mutunga M, Bejon P, Tsofa B, Agoti CN, Ochola-Oyier LI
Wellcome Open Res, (2020). 5:162

Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the alpha (3.7I) form of alpha-thalassaemia using genome-wide microarray data.Ndila CM, Nyirongo V, Macharia AW, Jeffreys AE, Rowlands K, Hubbart C, Busby GBJ, Band G, Harding RM, Rockett KA, Williams TN, Malaria GENConsortium
Wellcome Open Res, (2020). 5:287

Effectiveness of Rotarix ((R)) vaccine in Africa in the first decade of progressive introduction, 2009-2019: systematic review and meta-analysis.Murunga N, Otieno PG, Maia M, Agoti CN
Wellcome Open Res, (2020). 5:187

Mortality during and following hospital admission among school-aged children: a cohort study.Ngari MM, Obiero C, Mwangome MK, Nyaguara A, Mturi N, Murunga S, Otiende M, Iversen PO, Fegan GW, Walson JL, Berkley JA
Wellcome Open Res, (2020). 5:234

Pooled testing conserves SARS-CoV-2 laboratory resources and improves test turn-around time: experience on the Kenyan Coast.Agoti CN, Mutunga M, Lambisia AW, Kimani D, Cheruiyot R, Kiyuka P, Lewa C, Gicheru E, Tendwa M, Said Mohammed K, Osoti V, Makale J, Tawa B, Odundo C, Cheruiyot W, Nyamu W, Gumbi W, Mwacharo J, Nyamako L, Otieno E, Amadi D, Thoya J, Karani A, Mugo D, Musyoki J, Gumba H, Mwarumba S, Gichuki BM, Njuguna S, Riako D, Mutua S, Gitonga JN, Sein Y, Bartilol B, Mwangi SJ, Omuoyo DO, Morobe JM, de Laurent ZR, Bejon P, Ochola-Oyier LI, Tsofa B
Wellcome Open Res, (2020). 5:186

Surveillance of respiratory viruses among children attending a primary school in rural coastal Kenya.Adema IW, Kamau E, Uchi Nyiro J, Otieno GP, Lewa C, Munywoki PK, Nokes DJ
Wellcome Open Res, (2020). 5:63