Publications

Epidemiology and Demography

Prevalence, outcome and quality of care among children hospitalized with severe acute malnutrition in Kenyan hospitals: A multi-site observational study.Gachau S Irimu G Ayieko P Akech S Agweyu A English M Clinical Information Network Author Group
PLoS One, (2018). 13:e0197607

Human Coronavirus NL63 Molecular Epidemiology and Evolutionary Patterns in Rural Coastal Kenya.Kiyuka PK Agoti CN Munywoki PK Njeru R Bett A Otieno JR Otieno GP Kamau E Clark TG van der Hoek L Kellam P Nokes DJ Cotten M
J Infect Dis, (2018). 217:1728-1739

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with alpha(+)thalassaemia.Opi DH Swann O Macharia A Uyoga S Band G Ndila CM Harrison EM Thera MA Kone AK Diallo DA Doumbo OK Lyke KE Plowe CV Moulds JM Shebbe M Mturi N Peshu N Maitland K Raza A Kwiatkowski DP Rockett KA Williams TN Rowe JA
Elife, (2018). 7:

Continuous Invasion by Respiratory Viruses Observed in Rural Households During a Respiratory Syncytial Virus Seasonal Outbreak in Coastal Kenya.Munywoki PK Koech DC Agoti CN Cane PA Medley GF Nokes DJ
Clin Infect Dis, (2018). 67:1559-1567

Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial.Mallewa J Szubert AJ Mugyenyi P Chidziva E Thomason MJ Chepkorir P Abongomera G Baleeta K Etyang A Warambwa C Melly B Mudzingwa S Kelly C Agutu C Wilkes H Nkomani S Musiime V Lugemwa A Pett SL Bwakura-Dangarembizi M Prendergast AJ Gibb DM Walker AS Berkley JA Reality trial team
Lancet HIV, (2018). 5:e231-e240

Sickle Cell Anemia and Its Phenotypes.Williams TN Thein SL
Annu Rev Genomics Hum Genet, (2018). 19:113-147

Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children.Gilchrist JJ Mentzer AJ Rautanen A Pirinen M Mwarumba S Njuguna P Mturi N Wellcome Trust Case-Control Consortium Kenyan Bacteraemia Study Group Williams TN Scott JAG Hill AVS
Proc Natl Acad Sci U S A, (2018). 115:E3601-E3603

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.Gilchrist JJ Rautanen A Fairfax BP Mills TC Naranbhai V Trochet H Pirinen M Muthumbi E Mwarumba S Njuguna P Mturi N Msefula CL Gondwe EN MacLennan JM Chapman SJ Molyneux ME Knight JC Spencer CCA Williams TN MacLennan CA Scott JAG Hill AVS
Nat Commun, (2018). 9:1014

Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa.Aramburo A Todd J George EC Kiguli S Olupot-Olupot P Opoka RO Engoru C Akech SO Nyeko R Mtove G Gibb DM Babiker AG Maitland K
BMC Med, (2018). 16:37

Approaching quality improvement at scale: a learning health system approach in Kenya.Irimu G Ogero M Mbevi G Agweyu A Akech S Julius T Nyamai R Githang'a D Ayieko P English M Clinical Information Network Authors Group
Arch Dis Child, (2018). 103:1013-1019

Prospective Observational Study of Incidence and Preventable Burden of Childhood Tuberculosis, Kenya.Brent AJ Nyundo C Langat J Mulunda C Wambua J Bauni E Sande J Park K Williams TN Newton CRJ Levin M Scott JAG Kids Tb Study Group
Emerg Infect Dis, (2018). 24:514-523

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa.Taylor WR Naw HK Maitland K Williams TN Kapulu M D'Alessandro U Berkley JA Bejon P Okebe J Achan J Amambua AN Affara M Nwakanma D van Geertruyden JP Mavoko M Lutumba P Matangila J Brasseur P Piola P Randremanana R Lasry E Fanello C Onyamboko M Schramm B Yah Z Jones J Fairhurst RM Diakite M Malenga G Molyneux M Rwagacondo C Obonyo C Gadisa E Aseffa A Loolpapit M Henry MC Dorsey G John C Sirima SB Barnes KI Kremsner P Day NP White NJ Mukaka M
BMC Med, (2018). 16:11

Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa.McGann PT Williams TN Olupot-Olupot P Tomlinson GA Lane A Luis Reis da Fonseca J Kitenge R Mochamah G Wabwire H Stuber S Howard TA McElhinney K Aygun B Latham T Santos B Tshilolo L Ware RE Reach Investigators
Am J Hematol, (2018). 93:537-545

Appropriateness of clinical severity classification of new WHO childhood pneumonia guidance: a multi-hospital, retrospective, cohort study.Agweyu A Lilford RJ English M Clinical Information Network Author Group
Lancet Glob Health, (2018). 6:e74-e83

Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria.Kotlyar S Olupot-Olupot P Nteziyaremye J Akech SO Uyoga S Muhindo R Moore CL Maitland K
Pediatr Crit Care Med, (2018). 19:179-185

The clinical epidemiology of sickle cell anemia In Africa.Macharia AW Mochamah G Uyoga S Ndila CM Nyutu G Makale J Tendwa M Nyatichi E Ojal J Shebe M Awuondo KO Mturi N Peshu N Tsofa B Scott JAG Maitland K Williams TN
Am J Hematol, (2018). 93:363-370

Comparable outcomes among trial and nontrial participants in a clinical trial of antibiotics for childhood pneumonia: a retrospective cohort study.Agweyu A Oliwa J Gathara D Muinga N Allen E Lilford RJ English M
J Clin Epidemiol, (2018). 94:1-7

Blood Pressure and Arterial Stiffness in Kenyan Adolescents With the Sickle Cell Trait.Etyang AO Wandabwa CK Kapesa S Muthumbi E Odipo E Wamukoya M Ngomi N Haregu T Kyobutungi C Williams TN Makale J Macharia A Cruickshank JK Smeeth L Scott JAG
Am J Epidemiol, (2018). 187:199-205

Community Protection.Fine PEM Mulholland K Scott JA Edmunds WJ
Plotkin's Vaccines, (2018). :1512-1531.e5

Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia.Maitland K Kiguli S Opoka RO Olupot-Olupot P Engoru C Njuguna P Bandika V Mpoya A Bush A Williams TN Grieve R Sadique Z Fraser J Harrison D Rowan K
Wellcome Open Res, (2017). 2:100