(GASTRO): a Phase II rehydration study for severe dehydration: Plan C versus Slow rehydration

Although World Health Organization (WHO) rehydration management guidelines (Plan C) for severe dehydration are widely practiced in resource-poor settings, they have never formally been tested in a clinical trial, despite outcomes (mortality) in this group of children being poor. As the Fluid Expansion as a Supportive Therapy trial raised concerns regarding the safety of fluid bolus therapy for septic shock, we evaluated current recommendations (aggressive rehydration therapy) versus a slower more conservative rehydration regime in Ugandan/Kenyan with severe dehydration secondary to gastroenteritis. We found the slower regime giving rehydration therapy over 8 hours to be safe and for clinicians it was easier to implement than the aggressive two-stage Plan C regime recommended by WHO. Time correct signs of dehydration and hospital stay was similar in the two groups. Future large trials with mortality as the primary endpoint are warranted.

Read more here: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1356-z