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Management
Prof. Philip Bejon
Principal Investigator
Project Research
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Biography
Philip first came to Kenya in 2002 to conduct Phase I and IIb clinical trials of a candidate malaria vaccine based on viral vectors, working between the Jenner at University of Oxford and KEMRI-Wellcome. He returned to Oxford in 2006 to complete specialist clinical training as a clinical lecturer, and was appointed as a senior fellow in the NIHR Oxford Biomedical Research Centre in 2009. He remained active in malaria research during these posts, leading further trials of GSK’s candidate malaria vaccine “RTS,S”, and as a member of the Malaria Vectored Vaccine Consortium funded to test viral vectored malaria vaccines in several sites in Africa including Kenya. He was awarded an MRC Clinician-Scientist Fellowship in 2013 which allowed him to return to be resident full-time in Kenya again in 2013, working on malaria epidemiology.He has been the Executive Director of the KEMRI-Wellcome Trust Research Programme from September 2014 to January 2024. He enjoys opportunities to be involved in community engagement activities and fieldwork, and continue to be involved in patient care and clinical research where he can. He introduced real-time data entry with a field team during his PhD, and the Programme relies increasingly on direct electronic data entry. He has expertise in designing and leading clinical trials, field surveillance, laboratory science and statistical and modelling analyses, and also enjoys collaborating with colleagues in entomology and social sciences.
Current Work
Current work on malaria vaccines includes human malaria challenge models to study acquired host immunity to blood stage parasites in the aim of better defining natural immunity and correlates of natural immunity to guide vaccine development. This work is run by a large team. Work on challenge is overseen by Melissa Kapulu, clinical supervision by Mainga Hamaluba, and immunology work by Faith Osier, Francis Ndung'u, Abdirahman Abdi, Sam Kinyanjui and Cheryl Andisi (Pwani University). the team works closely with partners in Sanaria on the challenge. The team is also testing the Jenner (Oxford) and Serum Institute of India R21 vaccine (an RTS,S biosimilar), and also working with CDC-KEMRI and WRAIR-KEMRI on developing implementation trials of RTS,S. With Derrick Kimathi, Mainga Hamaluba and George Warimwe he works on Yellow Fever Vaccine trials, specifically on the non-inferiority of fractional doses of Yellow Fever Vaccine in order to facilitate vaccine supply. In collaboration with Epicentre MSF, UVRI and IP Dakar. He also works with Dominic Kwiatkowski and Irene Omedo on falciparum malaria genomics to examine the transmission steps observed in the field, to inform future malaria control strategies, and to track genomic changes in the parasite over 20 years in Kilifi County, Kenya. He work with Bob Snow and Alice Kamau on the epidemiology of malaria, examining estimates of the disease burden and of the infectious burden in Kilifi County and more widely across Africa.Collaborations
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Project Research
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Publications
Age-dependent acquisition of IgG antibodies to Shigella serotypes-a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination.
Kapulu, M. C., Muthumbi, E., Otieno, E., Rossi, O., Ferruzzi, P., Necchi, F., Acquaviva, A., Martin, L. B., Orindi, B., Mwai, K., Kibet, H., Mwanzu, A., Bigogo, G. M., Verani, J. R., Mbae, C., Nyundo, C., Agoti, C. N., Nakakana, U. N., Conti, V., Bejon, P., Kariuki, S., Scott, J. A. G., Micoli, F., Podda, A.
Front Immunol, (2024). 15:1340425
Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023.
Kapulu, M., Manda-Taylor, L., Balasingam, S., Means, G., Ayiro Malungu, M., Bejon, P., Chi, P. C., Chiu, C., Church, E. C., Correa-Oliveira, R., Day, N., Durbin, A., Egesa, M., Emerson, C., Jambo, K., Mathur, R., Metzger, W., Mumba, N., Nazziwa, W., Olotu, A., Rodgers, J., Sinyiza, F., Talaat, K., Kamerling, I., Weller, C., Baay, M., Neels, P.
Biologicals, (2024). :101747
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
Datoo, M. S., Dicko, A., Tinto, H., Ouédraogo, J. B., Hamaluba, M., Olotu, A., Beaumont, E., Ramos Lopez, F., Natama, H. M., Weston, S., Chemba, M., Compaore, Y. D., Issiaka, D., Salou, D., Some, A. M., Omenda, S., Lawrie, A., Bejon, P., Rao, H., Chandramohan, D., Roberts, R., Bharati, S., Stockdale, L., Gairola, S., Greenwood, B. M., Ewer, K. J., Bradley, J., Kulkarni, P. S., Shaligram, U., Hill, A. V. S.
Lancet, (2024). 403:533-544
Low frequency of Plasmodium falciparum hrp2/3 deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya.
Okanda, D., Ndwiga, L., Osoti, V., Achieng, N., Wambua, J., Ngetsa, C., Lubell-Doughtie, P., Shankar, A., Bejon, P., Ochola-Oyier, L. I.
Front Epidemiol, (2023). 3:1083114
Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected.
Kimenyi, K. M., Akinyi, M. Y., Mwikali, K., Gilmore, T., Mwangi, S., Omer, E., Gichuki, B., Wambua, J., Njunge, J., Obiero, G., Bejon, P., Langhorne, J., Abdi, A., Ochola-Oyier, L. I.
BMC Infect Dis, (2024). 24:140
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial.
Datoo, M. S., Dicko, A., Tinto, H., Ouédraogo, J. B., Hamaluba, M., Olotu, A., Beaumont, E., Ramos Lopez, F., Natama, H. M., Weston, S., Chemba, M., Compaore, Y. D., Issiaka, D., Salou, D., Some, A. M., Omenda, S., Lawrie, A., Bejon, P., Rao, H., Chandramohan, D., Roberts, R., Bharati, S., Stockdale, L., Gairola, S., Greenwood, B. M., Ewer, K. J., Bradley, J., Kulkarni, P. S., Shaligram, U., Hill, A. V. S.
Lancet, (2024). 403:533-544
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria.
Odera, D. O., Tuju, J., Mwai, K., Nkumama, I. N., Fürle, K., Chege, T., Kimathi, R., Diehl, S., Musasia, F. K., Rosenkranz, M., Njuguna, P., Hamaluba, M., Kapulu, M. C., Frank, R., Osier, F. H. A., Abdi, A. I., Chi, P. C., de Laurent, Z., Jao, I., Kamuya, D., Kamuyu, G., Makale, J., Murungi, L., Musyoki, J., Muthui, M., Mwacharo, J., Kariuki, S., Mwanga, D., Mwongeli, J., Ndungu, F., Njue, M., Nyangweso, G., Kimani, D., Ngoi, J. M., Musembi, J., Ngoto, O., Otieno, E., Ooko, M., Shangala, J., Wambua, J., Mohammed, K. S., Omuoyo, D., Mosobo, M., Kibinge, N., Kinyanjui, S., Bejon, P., Lowe, B., Marsh, K., Marsh, V., Abebe, Y., Billingsley, P. F., Sim, B. K. L., Hoffman, S. L., James, E. R., Richie, T. L., Audi, A., Olewe, F., Oloo, J., Ongecha, J., Ongas, M. O., Koskei, N., Bull, P. C., Hodgson, S. H., Kivisi, C., Imwong, M., Murphy, S. C., Ogutu, B., Tarning, J., Winterberg, M., Williams, T. N.
Sci Transl Med, (2023). 15:eabn5993
The CINAMR (Clinical Information Network-Antimicrobial Resistance) Project: A pilot microbial surveillance using hospitals linked to regional laboratories in Kenya: Study Protocol.
Akech, S., Nyamwaya, B., Gachoki, J., Ogero, M., Kigo, J., Maina, M., Mutua, E., Ooko, E., Bejon, P., Mwarumba, S., Bahati, F., Mvera, B., Musyimi, R., Onsare, R., Hutter, J., Tanui, E., Wesangula, E., Turner, P., Dunachie, S., Lucey, O., McKnight, J.
Wellcome Open Res, (2022). 7:256
Impact of COVID-19 on mortality in coastal Kenya: a longitudinal open cohort study.
Otiende, M., Nyaguara, A., Bottomley, C., Walumbe, D., Mochamah, G., Amadi, D., Nyundo, C., Kagucia, E. W., Etyang, A. O., Adetifa, I. M. O., Brand, S. P. C., Maitha, E., Chondo, E., Nzomo, E., Aman, R., Mwangangi, M., Amoth, P., Kasera, K., Ng'ang'a, W., Barasa, E., Tsofa, B., Mwangangi, J., Bejon, P., Agweyu, A., Williams, T. N., Scott, J. A. G.
Nat Commun, (2023). 14:6879
Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum.
Kioko, M., Pance, A., Mwangi, S., Goulding, D., Kemp, A., Rono, M., Ochola-Oyier, L. I., Bull, P. C., Bejon, P., Rayner, J. C., Abdi, A. I.
Nature Communications, (2023). 14:6447