Management

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Prof. Philip Bejon

Principal Investigator


Current Work

Current work on malaria vaccines includes human malaria challenge models to study acquired host immunity to blood stage parasites in the aim of better defining natural immunity and correlates of natural immunity to guide vaccine development. This work is run by a large team. Work on challenge is overseen by Melissa Kapulu, clinical supervision by Mainga Hamaluba, and immunology work by Faith Osier, Francis Ndung'u, Abdirahman Abdi, Sam Kinyanjui and Cheryl Andisi (Pwani University). the team works closely with partners in Sanaria on the challenge. The team is also testing the Jenner (Oxford) and Serum Institute of India R21 vaccine (an RTS,S biosimilar), and also working with CDC-KEMRI and WRAIR-KEMRI on developing implementation trials of RTS,S. With Derrick Kimathi, Mainga Hamaluba and George Warimwe he works on Yellow Fever Vaccine trials, specifically on the non-inferiority of fractional doses of Yellow Fever Vaccine in order to facilitate vaccine supply. In collaboration with Epicentre MSF, UVRI and IP Dakar. He also works with Dominic Kwiatkowski and Irene Omedo on falciparum malaria genomics to examine the transmission steps observed in the field, to inform future malaria control strategies, and to track genomic changes in the parasite over 20 years in Kilifi County, Kenya. He work with Bob Snow and Alice Kamau on the epidemiology of malaria, examining estimates of the disease burden and of the infectious burden in Kilifi County and more widely across Africa.

Collaborations

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