Dr Silvia Kariuki


Dr Silvia Kariuki

Post – Doc

Research group:


Silvia is an IDeAL early career post-doctoral fellow in the Host Genetic Factors group led by Professor Thomas Williams. She joined the programme in 2016 and is broadly interested in the genetic architecture of complex traits, and specifically identifying genetic factors associated with disease susceptibility. Her doctoral thesis work at the University of Chicago involved endophenotype mapping to identify novel genetic polymorphisms associated with complex traits such as systemic lupus erythematosus (SLE) and vitamin D response in the immune system. Her current post-doctoral project at the KEMRI-Wellcome Trust Research Program involves functional validation of several genetic polymorphisms that confer substantial protection against severe malaria. She is interested in characterising the molecular mechanisms through which these polymorphisms confer their protective effect through application of several experimental techniques such as flow cytometry-based parasite invasion assays and red blood cell membrane characterisation, as well as rosetting and cytoadhesion assays


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Successive Respiratory Syncytial Virus Epidemics in Local Populations Arise from Multiple Variant Introductions, Providing Insights into Virus Persistence

Agoti, C. N., Otieno, J. R., Ngama, M., Mwihuri, A. G., Medley, G. F., Cane, P. A., Nokes, D. J.

J Virol. 2015; : 11630-42

Local evolutionary patterns of human respiratory syncytial virus derived from whole-genome sequencing

Agoti, C. N., Otieno, J. R., Munywoki, P. K., Mwihuri, A. G., Cane, P. A., Nokes, D. J., Kellam, P., Cotten, M.

Journal of Virology. 2015; : 3444-54

Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya

Agoti, C. N., Mwihuri, A. G., Sande, C. J., Onyango, C. O., Medley, G. F., Cane, P. A., Nokes, D. J.

J Infect Dis. 2012; : 1532-41

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