I am a trained immunologist and vaccinologist having undertaken DPhil on malaria transmission-blocking vaccines at the University of Oxford. Following on from this, I served as a post-doc with Kevin Marsh and Philip Bejon at the KEMRI-Wellcome Trust Research Programme in Kilifi working on assessing the infectious reservoir of malaria. From 2015, portfolio of work expanded to setting up currently the largest single-site falciparum controlled human malaria infection study in 161 volunteers leading a diverse team in Kenya in collaboration with key partners in this field. The work centres around better understanding naturally acquired immunity for the design, development and testing of vaccines currently for the infectious diseases for malaria and Shigella. This involves developing and/or establishing tools and models to identify, characterise, understand, and evaluate vaccines, particularly the controlled human infection models, in disease endemic populations. We have established the controlled human malaria infection platform in Kilifi Kenya and furthermore, an enteric, Shigella, human infection model will be established and an establishment of an induced blood-stage malaria infection model within the same setting.