Eunice initially joined the Programme in Nairobi working on antimalarial drug resistance. In 2005 she transferred to Kilifi to pursue her interest in the immunology of infectious diseases under the Biology and Pathology of the Malaria Parasite (BiolMalPar) Ph.D. training programme. This was a collaborative programme with time spent between the UK and Kenya. Her thesis was on understanding host immune responses, specifically B-cell regulation in malaria. On returning to Kenya, she was awarded 6 months funding by BIOMALPAR/European Molecular Biology Laboratories (EMBL) a European Union Initiative to understand the role of soluble factors, such as the B cell activating factor (BAFF) on B-cell differentiation and function. She then successfully obtained a Wellcome Trust Training Fellowship, which has supported her current work on B-cell regulation in HIV infection and exposure. Her work aims at understanding whether exposure to HIV virus or antigens, antiretroviral drugs and/or an altered placental cytokine milieu, in utero, affects the developing immune system in infants born to HIV infected mothers but are themselves not infected. In HIV infection, she has been involved in understanding B cell phenotypic and functional changes in HIV infected children. In addition, understanding the influence of T cell-B cell interactions on resulting down-stream B cell function.
Eunice's current work involves understanding immune responses in early HIV infection and how this may impact on down stream disease control. Specifically she is interested in understanding HIV- specific T cell and B cell subsets and interactions that are predictive of downstream generation of broadly neutralizing antibodies. In addition, as part of the IAVI consortium she has been involved in establishing functional assays to examine breadth of CD8 T cell inhibitory activity and its impact on disease progression.
Nduati, E. W., Hassan, A. S., Knight, M. G., Muema, D. M., Jahangir, M. N., Mwaringa, S. L., Etyang, T. J., Rowland-Jones, S., Urban, B. C., Berkley, J. A.
BMC Public Health. 2015; : 1008
Nduati, E. W., Ng, D. H., Ndungu, F. M., Gardner, P., Urban, B. C., Langhorne, J.
PLoS One. 2010; : e15007
Muema, D. M., Macharia, G. N., Hassan, A. S., Mwaringa, S. M., Fegan, G. W., Berkley, J. A., Nduati, E. W., Urban, B. C.
Journal of Immunology. 2015; : 1082-91
Nduati, E., Gwela, A., Karanja, H., Mugyenyi, C., Langhorne, J., Marsh, K., Urban, B. C.
J Infect Dis. 2011; : 962-70
Afran, L., Garcia Knight, M., Nduati, E., Urban, B. C., Heyderman, R. S., Rowland-Jones, S. L.
Clinical and Experimental Immunology. 2014; : 11-22