We support the development of infrastructural capacity in a leading centre of clinical investigation in an area of hyper-endemic malaria transmission (i.e. the Mbale/Soroti Research Unit). The sites in Uganda are well suited for trials on critical care, oxygen delivery, sickle cell disease and other haemoglobinopathies, and to the description of the emerging and highly prevalent syndrome of “blackwater fever”.
Mbale and Soroti Regional Referral Hospitals in Eastern Uganda are in areas of perennial hyper-endemic malaria transmission. Work linked with the programme began in 2008 with multi-centre studies, and we supported the PhD studies for Dr Peter Olupot-Olupot, who is now the Director of the Mbale Clinical Research Unit. Our work will focus on malaria and its consequences in the region: direct morbidity and mortality (including the emergence of blackwater fever in children in this region) and the indirect consequences of malaria including bacterial infection, malnutrition and genetic polymorphisms including sickle cell disease and G6PD deficiency.