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Simon Ndirangu Muchohi

Dr Simon Ndirangu1.jpg
Email: 
sndiranguatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

Research

General research description not available.  See collaboartions, projects and publications.

Collaborations

Prof. Steve Ward
Liverpool School of Tropical Medicine
United Kingdom
Dr Geoffrey Edwards
School of Biomedical Sciences, University of Liverpool
United Kingdom
Prof. Gilbert Kokwaro
Department of Pharmaceutics and Pharmacy Practice, School of Pharmacy, University of Nairobi, Nairobi
Kenya
Prof Charles Newton
Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi & Neurosciences Unit, Institute of Child Health, University College London, London
Kenya
Dr Alexis Nzila
KEMRI -Wellcome Trust Research Programme, Kilifi
Kenya
Dr Bernhards Ogutu
Kenya Medical Research Institute, Centre for Clinical Research/Walter Reed Program, Kisumu
Kenya
Dr Martha Lemnge
National Institute for Medical Research, Tanga
Tanzania
Prof. Niklas LindegÄrdh
Faculty of Tropical Medicine, Mahidol University, Bangkok
Thailand

Publications

Selected Publications: 

Ikumi M.L., Muchohi S.N., Ohuma E.O., Kokwaro G.O. and Newton C.R. (2008). Response to diazepam in children with malaria induced seizures. Epilepsy Res 82(2-3): 215-8.

Muchohi S.N., Kokwaro G.O., Ogutu B.R., Edwards G., Ward S.A. and Newton C.R. (2008). Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions. Br J Clin Pharmacol 66(4): 529-38.

Muchohi S.N., Obiero K., Newton C.R., Ogutu B.R., Edwards G. and Kokwaro G.O. (2008). Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions. Br J Clin Pharmacol 65(1): 12-21.

Teka H., Petros B., Yamuah L., Tesfaye G., Elhassan I., Muchohi S., Kokwaro G., Aseffa A. and Engers H. (2008). Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia. Malar J. 7: 220.

Seaton C., Ignas J., Muchohi S., Kokwaro G., Maitland K. and Thomson A.H. (2007). Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition. J Antimicrob Chemother.

Kokwaro G.O., Muchohi S.N., Ogutu B.R. and Newton C.R. (2006). Chloramphenicol pharmacokinetics in African children with severe malaria. J Trop Pediatr 52(4): 239-43.

Muchohi S.N., Obiero K., Kokwaro G.O., Ogutu B.R., Githiga I.M., Edwards G. and Newton C.R. (2005). Determination of lorazepam in plasma from children by high-performance liquid chromatography with UV detection. J Chromatogr B Analyt Technol Biomed Life Sci 824(1-2): 333-40.

Muchohi S.N., Ward S.A., Preston L., Newton C.R., Edwards G. and Kokwaro G.O. (2005). Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children. J Chromatogr B Analyt Technol Biomed Life Sci 821(1): 1-7.

Mithwani S., Aarons L., Kokwaro G.O., Majid O., Muchohi S., Edwards G., Mohamed S., Marsh K. and Watkins W. (2004). Population pharmacokinetics of artemether and dihydroartemisinin following single intramuscular dosing of artemether in African children with severe falciparum malaria. Br J Clin Pharmacol 57(2): 146-52.

Kokwaro G.O., Ogutu B.R., Muchohi S.N., Otieno G.O. and Newton C.R. (2003). Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions. Br J Clin Pharmacol 56(4): 453-7.
Ogutu B.R., Newton C.R., Muchohi S.N., Otieno G.O., Edwards G., Watkins W.M. and Kokwaro G.O. (2003).

Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus. Br J Clin Pharmacol. 56: 112-9.

Thomson A.H., Kokwaro G.O., Muchohi S.N., English M., Mohammed S. and Edwards G. (2003). Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected severe sepsis in Kenya. Br J Clin Pharmacol 56(1): 25-31.

Ogutu B.R., Newton C.R., Crawley J., Muchohi S.N., Otieno G.O., Edwards G., Marsh K. and Kokwaro G.O. (2002). Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions. Br J Clin Pharmacol 53(1): 49-57.

Ogutu B.R., Newton C.R., Muchohi S.N., Otieno G.O. and Kokwaro G.O. (2002). Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. Br J Clin Pharmacol 54(6): 635-42.

Muchohi S.N., Ogutu B.R., Newton C.R. and Kokwar G.O. (2001). High-performance liquid chromatographic determination of diazepam in plasma of children with severe malaria. J Chromatogr B Biomed Sci Appl 761(2): 255-9.