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D James Nokes
kilifi [dot] kemri-wellcome [dot] org Research
Research area
Epidemiology and control of viral pathogens
Research overview
Our research centres on the epidemiology of medically important viral pathogens in the developing country setting, in particular respiratory syncytial virus (RSV) and rotavirus. The emphasis is on improved understanding of the determinants of infection dynamics, in relation to host behaviour, demography and immunity, and of parasite transmissibility and antigenic diversity, and to provide a framework for the rational design of control programmes. Projects combine community-based studies in households and schools, immunology and molecular characterisation, and mathematical and statistical modelling. The research is multidisciplinary and collaborative, with applications to public health policy.
Collaborations
Publications
Nokes DJ, Peenze I, Netshifhefhe L, Abwao J, De Beer MC, Seheri LM, Williams TN, Page N, Steele AD. Rotavirus genetic diversity, disease association and temporal change in hospitalized rural Kenyan children. Journal of Infectious Disease 2009 (in press.)
Nokes DJ, Ngama MJ, Bett A, Abwao J, Munywoki P, English M, Scott JAG, Cane PA, Medley GF. Incidence and severity of respiratory syncytial virus pneumonia in rural Kenyan children identified through hospital surveillance. Clinical Infectious Diseases 2009 49:1341-9.
Medley GF, Nokes DJ. Does viral diversity matter? Epidemiology Perspectives. Science 2009; 325:274-5.
White LJ, Buttery J, Cooper B, Nokes DJ and Medley GF. Rotavirus within day care centres in Oxfordshire, UK: characterization of partial immunity. J R Soc Interface 2008;5:1481-90
Nokes DJ, Abwao J, Pamba A, Peenze I, Dewar J, Maghenda JK, Gatakaa H, Bauni E, Scott JA, Maitland K, Williams TN. Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya. PLoS Med 2008;5:e153
Nokes, D. J., Okiro, E. A., Ngama, M., Ochola, R., White, L. J., Scott, P. D., English, M., Cane, P. A., and Medley, G. F. Respiratory syncytial virus infection and disease in infants and young children studied from birth in Kilifi District, Kenya. Clinical Infectious Diseases, 2008, 46:50-7.
Scott, P. D., Ochola, R., Sande, C., Ngama, M., Okiro, E. A., Medley, G. F., Nokes, D., and Cane, P. A. Comparison of strain specific antibody responses during primary and secondary infections with respiratory syncytial virus. Journal of Medical Virology, 2007, 79: 1943-50.
White, L.J., Mandl, J.N., Gomes, M.G.M., Bodley-Tickell, A.T., Cane, P.A., Perez-Brena, P., Aguilar, J.C., Siqueira, M.M., Portes, S.A., Straliotto, S.M., Waris, M., Nokes, D.J.,& Medley, G.F. Understanding the transmission dynamics of respiratory syncytial virus using multiple time series and nested models. Mathematical Biosciences 2007, 209, 222-39.
Scott, P. D., Ochola, R., Ngama, M., Okiro, E. A., Nokes, D. J., Medley, G. F. & Cane, P. A. Molecular analysis of respiratory syncytial virus reinfections in infants from coastal Kenya. Journal of Infectious Diseases 2006, 193: 59-67.
White, L. J., Waris, M., Cane, P. A., Nokes, D. J. & Medley, G. F. The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection. Epidemiology and Infection 2005, 133: 279-89.