Rosie is a paediatrician with a broad research interest in child health in low income settings. After her first degree at Cambridge University she completed medical school at University College London, then worked in the UK National Health Service for five years as a junior doctor. During this time she first visited Kilifi in 2011-12 as an Academic Clinical Fellow in Paediatrics with the University of Oxford. She worked with Laura Hammitt and Anthony Scott in Kilifi to characterise population serological immunity to Haemophilus influenzae type B – a bacteria that causes pneumonia and meningitis in infants and young children. After returning to the UK to complete a Masters in Epidemiology at the London School of Hygiene & Tropical Medicine, Rosie is now a Wellcome Trust Research Training Fellow in Kilifi. Her Fellowship focuses on the aetiology of Environmental Enteric Dysfunction (EED) – small intestinal inflammation and loss of absorptive surface area seen amongst many infants and children in tropical low income settings. Rosie is supervised by Prof. Jay Berkley in Kilifi and Prof. Holm Uhlig at Oxford University.
1. ‘Epidemiology of Environmental Enteric Dysfunction and intestinal microbiota amongst infants in Kilifi, Kenya.’ Rosie is Principal Investigator of a birth cohort study in rural Kilifi that aims to improve our understanding of the causes and pattern of acquisition of inflammation and loss of absorptive surface area in the small intestine. This condition - Environmental Enteric Dysfunction (EED) - is poorly understood but thought to be very common in tropical low income settings - taking hold during early infancy and persisting into late childhood and beyond. EED is strongly associated with stunting (low height for age) which in turn is associated with greatly increased morbidity and mortality from infection during childhood. Improving our understanding of EED and its causes will improve our ability to prevent and treat stunting, thus averting its significant impacts on child health. 2. ‘Mapping the spatial, social and environmental burden of malnutrition and its determinants in Kenya.’ Rosie is a team member for this project, where she is assisting with mapping and small-area censuses in rural Kilifi, Turkana and Kisumu, and in the Mathare area of Nairobi. Data regarding the spatial distribution of malnutrition (stunting, wasting, low weight for age) within Kenya are variable and often sparse. Our understanding of the complex interplay between the likely many determinants of childhood malnutrition (environmental, social, biological, political) is evolving. These associations are themselves likely to vary by location within Kenya, and over time. This project aims - through analysis of existing large datasets and creation of new data via small area mapping and censuses - to improve understanding of these associations and subsequently produce tools for use by stakeholders in monitoring, prevention and management of childhood malnutrition at scale. The small area census aspect aims to ‘fill in the gaps’ left by the existing large datasets - to examine the spatial epidemiology of childhood malnutrition at higher resolution and in contrasting ecological settings within Kenya.
Crane, R. J., Jones, K. D., Berkley, J. A.
Food Nutr Bull. 2015; : S76-87
Hammitt, L.L. Crane, R.J. Karani, A. Mutuku, A. Morpeth, S.C. Burbidge, P. Goldblatt, D. Kamau, T. Sharif, S. Mturi, N. Scott, J.A.
Lancet global health, 2016,Volume: 4,Issue: 3. ; :