James trained in Zoology followed by a PhD in viral epidemiology, out of which developed an enduring interest in the transmission dynamics and control of human viral pathogens. A post-doc period at Imperial College was followed by two years at Oxford and then Warwick from 1995, which remains his home institution where he is a Professor of Infectious Disease Epidemiology. His research initially centred on vaccine-preventable diseases such as measles and HBV and involved collaborative studies in Ethiopia. In 2001, James' interests shifted to the study of respiratory syncytial virus (RSV) accompanying a move of scientific base to the KEMRI-Wellcome Trust Research Programme (KWTRP) in Kilifi, Kenya. This fascinating, antigenically diverse virus - a major cause of childhood pneumonia - remains a focus of his research up to today. Currently, he heads the Virus Epidemiology and Control Research Group within the Epidemiology and Demography Department, with research support primarily from a Wellcome Trust Senior Investigator Award.
My research focuses on a range of medically important respiratory and enteric viral pathogens, in particular respiratory syncytial virus (RSV) and rotavirus. The research objective is to improve understanding of infection dynamics, in relation to host behaviour, demography and immunity, and of parasite transmissibility and antigenic diversity, and to provide a framework for the rational design of control programmes. Projects combine community-based studies in households and schools, immunology and molecular characterisation, and mathematical and statistical modelling. The research is multidisciplinary and collaborative, with applications to public health policy. The team of scientists involved form the Virus Epidemiology and Control Research Group (http://www.virec-group.org), and is based in the Epidemiology and Demography Department.
Agoti, C. N., Otieno, J. R., Ngama, M., Mwihuri, A. G., Medley, G. F., Cane, P. A., Nokes, D. J.
J Virol. 2015; : 11630-42
Sande, C. J., Mutunga, M. N., Medley, G. F., Cane, P. A., Nokes, D. J.
J Infect Dis. 2013; : 489-92
Ohuma, E. O., Okiro, E. A., Ochola, R., Sande, C. J., Cane, P. A., Medley, G. F., Bottomley, C., Nokes, D. J.
Am J Epidemiol. 2012; : 794-802
Kinyanjui, T. M., House, T. A., Kiti, M. C., Cane, P. A., Nokes, D. J., Medley, G. F.
PLoS One. 2015; : e0138018
Munywoki, P. K., Koech, D. C., Agoti, C. N., Lewa, C., Cane, P. A., Medley, G. F., Nokes, D. J.
J Infect Dis. 2014; : 1685-92